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Cadherin

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(New page: Crystal Structure of Cadherin, 1q1p {{STRUCTURE_1q1p| PDB=1q1p | SIZE=300| SCENE= |right|CAPTION=Cadherin, 1q1p }} '''Cadherins''' (CDH) are ...)
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CDH encoded by CDH1
 
-
1q1p – mCDH1 - mouse
+
=== CDH encoded by CDH1 ===
-
CDH encoded by CDH5
 
-
2koh mCDH5+PAR3-PDZ3
+
[[1q1p]] mCDH1 - mouse<br />
-
CDH encoded by CDH6
 
-
3lnd – mCDH6 EC12 (mutant)
+
=== CDH encoded by CDH5 ===
-
CDH encoded by CDH8
 
-
1zxk mCDH8 EC1
+
[[2koh]] mCDH5+PAR3-PDZ3<br />
-
2a62 - mCDH8 EC1+EC2+EC3
+
-
CDH encoded by CDH11
 
-
2a4c, 2a4e – mCDH11 EC1
+
=== CDH encoded by CDH6 ===
-
CDH encoded by CDH20
 
-
1zvn cCDH20 EC1 – chicken
+
[[3lnd]] mCDH6 EC12 (mutant)<br />
-
CDH encoded by CDH23
 
-
3mvs, 2whv – mCDH23 N-terminal
+
=== CDH encoded by CDH8 ===
-
2kbr – hCDH23 peptide+harmonin – NMR - human
+
-
2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR
+
-
C-CDH “classical”
 
-
1l3w XlC-CDH ectodomain - Xenopus laevis
+
[[1zxk]] mCDH8 EC1<br />
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1q5b, 1q5c – C-CDH model into desmosome – electron tomography
+
[[2a62]] - mCDH8 EC1+EC2+EC3<br />
-
E-CDH epithelial
 
-
1ff5 – mE-CDH double domain
+
=== CDH encoded by CDH11 ===
-
1edh - mE-CDH EC1+EC2+Ca
+
-
1suh – mE-CDH N-terminal - NMR
+
-
3l6x, 3l6y, 1i7x, 1i7w – mE-CDH+catenin
+
-
3lne, 3lnf, 3lng, 3lnh, 3lni – mE-CDH EC12 (mutant)
+
-
3ifq – hE-CDH EC1+EC2+EC3
+
-
2o72 - hE-CDH EC1+EC2
+
-
3ff7, 3ff8 - hE-CDH EC1+EC2+EC3+NK cell receptor
+
-
2qvf – mE-CDH1 CDH2
+
-
2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)
+
-
1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes
+
-
T-CDH membrane bound
 
-
3k5r mT-CDH EC1+EC2
+
[[2a4c]], [[2a4e]] mCDH11 EC1<br />
-
3k5s - cT-CDH EC1+EC2
+
-
3k6d - XlT-CDH EC1
+
-
3k6f - mT-CDH EC1
+
-
3k6i - cT-CDH EC1
+
-
2v37 – hT-CDH N-terminal - NMR
+
-
N-CDH neuronal
 
-
1nch, 1nci – mN-CDH
+
=== CDH encoded by CDH20 ===
-
1ncg – mN-CDH (mutant)
+
-
2qvi – mN-CDH EC12
+
-
1ncj – mN-CDH two domains
+
-
Protocadherin
 
-
2yst hProt-CDH7 EC3 NMR
+
[[1zvn]] cCDH20 EC1 chicken<br />
-
Desmoglein
 
-
2yqg – hDes-CDH EC1
+
=== CDH encoded by CDH23 ===
 +
 
 +
 
 +
[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />
 +
[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br />
 +
[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br />
 +
 
 +
 
 +
=== C-CDH “classical” ===
 +
 
 +
 
 +
[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br />
 +
[[1q5b]], [[1q5c]] – C-CDH model into desmosome – electron tomography<br />
 +
 
 +
 
 +
=== E-CDH epithelial ===
 +
 
 +
 
 +
[[1ff5]] – mE-CDH double domain<br />
 +
[[1edh]] - mE-CDH EC1+EC2+Ca<br />
 +
[[1suh]] – mE-CDH N-terminal - NMR<br />
 +
[[3l6x]], [[3l6y]], [[1i7x]], [[1i7w]] – mE-CDH+catenin<br />
 +
[[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]] – mE-CDH EC12 (mutant)<br />
 +
[[3ifq]] – hE-CDH EC1+EC2+EC3 <br />
 +
[[2o72]] - hE-CDH EC1+EC2<br />
 +
[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br />
 +
[[2qvf]] – mE-CDH1 CDH2<br />
 +
[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
 +
[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
 +
 
 +
 
 +
=== T-CDH membrane bound ===
 +
 
 +
 
 +
[[3k5r]] – mT-CDH EC1+EC2<br />
 +
[[3k5s]] - cT-CDH EC1+EC2 <br />
 +
[[3k6d]] - XlT-CDH EC1 <br />
 +
[[3k6f]] - mT-CDH EC1<br />
 +
[[3k6i]] - cT-CDH EC1<br />
 +
[[2v37]] – hT-CDH N-terminal - NMR<br />
 +
 
 +
 
 +
=== N-CDH neuronal ===
 +
 
 +
 
 +
[[1nch]], [[1nci]] – mN-CDH<br />
 +
[[1ncg]] – mN-CDH (mutant)<br />
 +
[[2qvi]] – mN-CDH EC12<br />
 +
[[1ncj]] – mN-CDH two domains<br />
 +
 
 +
 
 +
=== Protocadherin ===
 +
 
 +
 
 +
[[2yst]] – hProt-CDH7 EC3 – NMR<br />
 +
 
 +
 
 +
=== Desmoglein ===
 +
 
 +
 
 +
[[2yqg]] – hDes-CDH EC1<br />

Revision as of 11:37, 16 September 2010

Image:1q1p.png
Crystal Structure of Cadherin, 1q1p

Template:STRUCTURE 1q1p

Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), T-CDH bound to membrane, N-CDH (neurons). The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, i.e. the crystal structure of Cadherin (1q1p). Calcium ions is shown as a space filling objects.

3D Structures of Cadherin

CDH encoded by CDH1

1q1p – mCDH1 - mouse


CDH encoded by CDH5

2koh – mCDH5+PAR3-PDZ3


CDH encoded by CDH6

3lnd – mCDH6 EC12 (mutant)


CDH encoded by CDH8

1zxk – mCDH8 EC1
2a62 - mCDH8 EC1+EC2+EC3


CDH encoded by CDH11

2a4c, 2a4e – mCDH11 EC1


CDH encoded by CDH20

1zvn – cCDH20 EC1 – chicken


CDH encoded by CDH23

3mvs, 2whv – mCDH23 N-terminal
2kbr – hCDH23 peptide+harmonin – NMR - human
2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR


C-CDH “classical”

1l3w – XlC-CDH ectodomain - Xenopus laevis
1q5b, 1q5c – C-CDH model into desmosome – electron tomography


E-CDH epithelial

1ff5 – mE-CDH double domain
1edh - mE-CDH EC1+EC2+Ca
1suh – mE-CDH N-terminal - NMR
3l6x, 3l6y, 1i7x, 1i7w – mE-CDH+catenin
3lne, 3lnf, 3lng, 3lnh, 3lni – mE-CDH EC12 (mutant)
3ifq – hE-CDH EC1+EC2+EC3
2o72 - hE-CDH EC1+EC2
3ff7, 3ff8 - hE-CDH EC1+EC2+EC3+NK cell receptor
2qvf – mE-CDH1 CDH2
2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)
1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes


T-CDH membrane bound

3k5r – mT-CDH EC1+EC2
3k5s - cT-CDH EC1+EC2
3k6d - XlT-CDH EC1
3k6f - mT-CDH EC1
3k6i - cT-CDH EC1
2v37 – hT-CDH N-terminal - NMR


N-CDH neuronal

1nch, 1nci – mN-CDH
1ncg – mN-CDH (mutant)
2qvi – mN-CDH EC12
1ncj – mN-CDH two domains


Protocadherin

2yst – hProt-CDH7 EC3 – NMR


Desmoglein

2yqg – hDes-CDH EC1

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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