Ubiquitin
From Proteopedia
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| - | [[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]] – hUBB – NMR | + | [[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]] – hUBB – NMR<br /> |
| - | [[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]] - hUBB | + | [[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]] - hUBB<br /> |
| - | [[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]] - hUBB (mutant) | + | [[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]] - hUBB (mutant)<br /> |
| - | [[1c3t]], [[1ud7]] - hUBB (mutant) - NMR | + | [[1c3t]], [[1ud7]] - hUBB (mutant) - NMR<br /> |
| - | [[1gjz]] – hUBB N-terminal – NMR | + | [[1gjz]] – hUBB N-terminal – NMR<br /> |
| - | [[1e0q]] - hUBB N-terminal (mutant) – NMR | + | [[1e0q]] - hUBB N-terminal (mutant) – NMR<br /> |
| - | [[2k39]] – UBB – ''Xenopus laevis'' – NMR | + | [[2k39]] – UBB – ''Xenopus laevis'' – NMR<br /> |
| - | [[2jwz]], [[1zw7]] – yUBB (mutant) – yeast | + | [[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br /> |
| - | [[1cmx]] – yUBB (modified) | + | [[1cmx]] – yUBB (modified)<br /> |
| - | [[2zcc]] – bUBB - bovine | + | [[2zcc]] – bUBB - bovine<br /> |
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| - | [[3cmm]] – yUBB+E1 | + | [[3cmm]] – yUBB+E1 <br /> |
| - | [[3k9p]], [[3a33]] – hUBB+E2 | + | [[3k9p]], [[3a33]] – hUBB+E2<br /> |
| - | [[2gmi]] - hUBB+E2+MMS2 | + | [[2gmi]] - hUBB+E2+MMS2<br /> |
| - | [[2kjh]], [[1zgu]] – hUBB (mutant)+E2 | + | [[2kjh]], [[1zgu]] – hUBB (mutant)+E2<br /> |
| - | [[3jvz]], [[3jw0]] – hUBB+E2+E3 | + | [[3jvz]], [[3jw0]] – hUBB+E2+E3<br /> |
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| - | [[2kx0]] – hUBB+1 – human – NMR | + | [[2kx0]] – hUBB+1 – human – NMR<br /> |
| - | [[3k9o]] – hUBB+1+E2 | + | [[3k9o]] – hUBB+1+E2<br /> |
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| - | [[2xk5]], [[3nob]], [[2xew]], [[3h7p]], [[3h7s]], [[2w9n]], [[2jf5]] – hDiUBB | + | [[2xk5]], [[3nob]], [[2xew]], [[3h7p]], [[3h7s]], [[2w9n]], [[2jf5]] – hDiUBB<br /> |
| - | [[3m3j]], [[1aar]] – bDiUBB | + | [[3m3j]], [[1aar]] – bDiUBB <br /> |
| - | [[2bgf]] – hDiUBB – chemical relaxation | + | [[2bgf]] – hDiUBB – chemical relaxation<br /> |
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| - | [[3alb]], [[3hm3]], [[2o6v]], [[1f9j]], [[1tbe]] – tetra-hUBB | + | [[3alb]], [[3hm3]], [[2o6v]], [[1f9j]], [[1tbe]] – tetra-hUBB<br /> |
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[[3ofi]] – hUBB+insulin protease | [[3ofi]] – hUBB+insulin protease | ||
| - | [[3n3k]], [[3ifw]], [[3kvf]], [[3kw5]], [[3irt]], [[3mtn]], [[3ihp]] – hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain | + | [[3n3k]], [[3ifw]], [[3kvf]], [[3kw5]], [[3irt]], [[3mtn]], [[3ihp]] – hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain<br /> |
| - | [[3i3t]], [[2ibi]], [[2ayo]], [[1nbf]] - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain | + | [[3i3t]], [[2ibi]], [[2ayo]], [[1nbf]] - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br /> |
| - | [[2hd5]] - bUBB+hUBB carboxyl-terminal hydrolase catalytic domain | + | [[2hd5]] - bUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br /> |
| - | [[3ldz]] – bUBB+signal transducing adapter molecule | + | [[3ldz]] – bUBB+signal transducing adapter molecule<br /> |
| - | [[2khw]] – hUBB+immunoglobulin G-binding protein G | + | [[2khw]] – hUBB+immunoglobulin G-binding protein G<br /> |
| - | [[2kdi]] – yUBB/UIM fusion | + | [[2kdi]] – yUBB/UIM fusion <br /> |
| - | [[1v80]], [[1v81]] – bUBB/L40 ribosomal protein fusion - NMR | + | [[1v80]], [[1v81]] – bUBB/L40 ribosomal protein fusion - NMR<br /> |
| - | [[1yx5]], [[1yx6]] - hUBB+26S proteasome non-ATPase regulatory subunit – NMR | + | [[1yx5]], [[1yx6]] - hUBB+26S proteasome non-ATPase regulatory subunit – NMR<br /> |
| - | [[2k6d]] – hUBB+SH3 domain-containing kinase-binding protein – NMR | + | [[2k6d]] – hUBB+SH3 domain-containing kinase-binding protein – NMR<br /> |
| - | [[2z59]] – hUBB+mProtein Adhesion-regulating molecule 1 | + | [[2z59]] – hUBB+mProtein Adhesion-regulating molecule 1<br /> |
| - | [[2jy6]] – hUBB+hUbiquilin – NMR | + | [[2jy6]] – hUBB+hUbiquilin – NMR<br /> |
| - | 3by4, 3c0r – hUBB+yUBB thioesterase | + | [[3by4]], [[3c0r]] – hUBB+yUBB thioesterase<br /> |
| - | 2jt4 – yUBB fragment+cytoskeleton assembly control protein | + | [[2jt4]] – yUBB fragment+cytoskeleton assembly control protein<br /> |
| - | 2hth – hUBB+vacuolar protein sorting protein | + | [[2hth]] – hUBB+vacuolar protein sorting protein<br /> |
| - | 2dx5, 1p3q - bUBB+vacuolar protein sorting protein | + | [[2dx5]], [[1p3q]] - bUBB+vacuolar protein sorting protein<br /> |
| - | 1q0w - yUBB+vacuolar protein sorting protein | + | [[1q0w]] - yUBB+vacuolar protein sorting protein<br /> |
| - | 2g3q – yUBB+EDE1 UBA | + | [[2g3q]] – yUBB+EDE1 UBA<br /> |
| - | 2c7m, 2c7n, 2fid, 2fif – bUBB+RAB guanine nucleotide exchange factor | + | [[2c7m]], [[2c7n]], [[2fid]], [[2fif]] – bUBB+RAB guanine nucleotide exchange factor<br /> |
| - | 2d3g – bUBB+HRS-UIM | + | [[2d3g]] – bUBB+HRS-UIM<br /> |
| - | 1wrd – bUBB+TOM1 GAT domain | + | [[1wrd]] – bUBB+TOM1 GAT domain<br /> |
| - | 1wr6, 1yd8 - bUBB+GGA3 GAT domain | + | [[1wr6]], [[1yd8]] - bUBB+GGA3 GAT domain<br /> |
| - | 1wr1 – yUBB+DSK2P UBA | + | [[1wr1]] – yUBB+DSK2P UBA<br /> |
| - | 1s1q – hUBB+tumor susceptibility gene 101 protein | + | [[1s1q]] – hUBB+tumor susceptibility gene 101 protein<br /> |
| - | 1q5w – hUBB+NPL4 zinc-fingers | + | [[1q5w]] – hUBB+NPL4 zinc-fingers<br /> |
| - | 1uzx – bUBB+VPS23 UEV | + | [[1uzx]] – bUBB+VPS23 UEV<br /> |
| - | 1otr – yUBB+CUE2 | + | [[1otr]] – yUBB+CUE2<br /> |
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| - | 3a9j, 3a9k, 2wwz, 2wx0, 2wx1 – hDiUBB+mitogen-activated protein kinase | + | [[3a9j]], [[3a9k]], [[2wwz]], [[2wx0]], [[2wx1]] – hDiUBB+mitogen-activated protein kinase<br /> |
| - | 3jsv, 2zvn, 2zvo – hDiUBB+NF-κ-b essential modulator | + | [[3jsv]], [[2zvn]], [[2zvo]] – hDiUBB+NF-κ-b essential modulator<br /> |
| - | 2kde, 2kdf – DiUBB+26S proteasome non-ATPase regulatory subunit – NMR | + | [[2kde]], [[2kdf]] – DiUBB+26S proteasome non-ATPase regulatory subunit – NMR<br /> |
| - | 3a1q – mDiUBB+UBB interaction motif-containing protein – mouse | + | [[3a1q]] – mDiUBB+UBB interaction motif-containing protein – mouse<br /> |
| - | 3dvg, 3dvn – hDiUBB+IGG1 fab light&heavy chains | + | [[3dvg]], [[3dvn]] – hDiUBB+IGG1 fab light&heavy chains<br /> |
| - | 2znv – mDiUBB+hAMSH-like protease | + | [[2znv]] – mDiUBB+hAMSH-like protease<br /> |
=== Ubiquitin + ions === | === Ubiquitin + ions === | ||
| - | 3h1u – bUBB+Cd | + | [[3h1u]] – bUBB+Cd<br /> |
| - | 3ehv, 3eec, 3efu – hUBB+ions | + | [[3ehv]], [[3eec]], [[3efu]] – hUBB+ions<br /> |
Revision as of 14:35, 20 September 2010
Ubiquitin (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. At least 4 UBB molecules are needed to tag a protein for the proteasome. The images at the left and at the right correspond to one representative Ubiquitin, i.e. the NMR structure of human Ubiquitin (1d3z).
Contents |
3D Structures of Ubiquitin
Ubiquitin
2kn5, 2klg, 2jzz, 2pe9, 2pea, 1g6j, 1d3z – hUBB – NMR
2ojr, 2nr2, 2fcq, 1ubi, 1ubq - hUBB
2zcb, 2gbj, 2gbk, 2gbm, 2gbn, 2gbr, 2fcm, 2fcn, 2fcs, 1yiw, 1yj1, 1sif, 1ogw - hUBB (mutant)
1c3t, 1ud7 - hUBB (mutant) - NMR
1gjz – hUBB N-terminal – NMR
1e0q - hUBB N-terminal (mutant) – NMR
2k39 – UBB – Xenopus laevis – NMR
2jwz, 1zw7 – yUBB (mutant) – yeast
1cmx – yUBB (modified)
2zcc – bUBB - bovine
Ubiquitin+UBB-activating enzymes
3cmm – yUBB+E1
3k9p, 3a33 – hUBB+E2
2gmi - hUBB+E2+MMS2
2kjh, 1zgu – hUBB (mutant)+E2
3jvz, 3jw0 – hUBB+E2+E3
Ubiquitin+1 mutant
2kx0 – hUBB+1 – human – NMR
3k9o – hUBB+1+E2
Ubiquitin dimer
2xk5, 3nob, 2xew, 3h7p, 3h7s, 2w9n, 2jf5 – hDiUBB
3m3j, 1aar – bDiUBB
2bgf – hDiUBB – chemical relaxation
Ubiquitin tetramer
3alb, 3hm3, 2o6v, 1f9j, 1tbe – tetra-hUBB
Ubiquitin bound to protein
3ofi – hUBB+insulin protease
3n3k, 3ifw, 3kvf, 3kw5, 3irt, 3mtn, 3ihp – hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain
3i3t, 2ibi, 2ayo, 1nbf - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain
2hd5 - bUBB+hUBB carboxyl-terminal hydrolase catalytic domain
3ldz – bUBB+signal transducing adapter molecule
2khw – hUBB+immunoglobulin G-binding protein G
2kdi – yUBB/UIM fusion
1v80, 1v81 – bUBB/L40 ribosomal protein fusion - NMR
1yx5, 1yx6 - hUBB+26S proteasome non-ATPase regulatory subunit – NMR
2k6d – hUBB+SH3 domain-containing kinase-binding protein – NMR
2z59 – hUBB+mProtein Adhesion-regulating molecule 1
2jy6 – hUBB+hUbiquilin – NMR
3by4, 3c0r – hUBB+yUBB thioesterase
2jt4 – yUBB fragment+cytoskeleton assembly control protein
2hth – hUBB+vacuolar protein sorting protein
2dx5, 1p3q - bUBB+vacuolar protein sorting protein
1q0w - yUBB+vacuolar protein sorting protein
2g3q – yUBB+EDE1 UBA
2c7m, 2c7n, 2fid, 2fif – bUBB+RAB guanine nucleotide exchange factor
2d3g – bUBB+HRS-UIM
1wrd – bUBB+TOM1 GAT domain
1wr6, 1yd8 - bUBB+GGA3 GAT domain
1wr1 – yUBB+DSK2P UBA
1s1q – hUBB+tumor susceptibility gene 101 protein
1q5w – hUBB+NPL4 zinc-fingers
1uzx – bUBB+VPS23 UEV
1otr – yUBB+CUE2
Ubiquitin dimer bound to protein
3a9j, 3a9k, 2wwz, 2wx0, 2wx1 – hDiUBB+mitogen-activated protein kinase
3jsv, 2zvn, 2zvo – hDiUBB+NF-κ-b essential modulator
2kde, 2kdf – DiUBB+26S proteasome non-ATPase regulatory subunit – NMR
3a1q – mDiUBB+UBB interaction motif-containing protein – mouse
3dvg, 3dvn – hDiUBB+IGG1 fab light&heavy chains
2znv – mDiUBB+hAMSH-like protease
Ubiquitin + ions
3h1u – bUBB+Cd
3ehv, 3eec, 3efu – hUBB+ions
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, David Canner, Jaime Prilusky
