Proteasome
From Proteopedia
(New page: Crystal Structure of Proteasome, 3gpt {{STRUCTURE_3gpt| PDB=3gpt | SIZE=300| SCENE= |right|CAPTION=Proteasome, 3gpt }} Proteasome (PRTS) are...) |
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| - | Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 alpha subunits which form the PRTS gate. The two inner rings contain 6 beta subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which binds polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, ''i.e.'' the crystal structure of yeast Proteasome ([[3gpt]]). | + | [[Proteasome]] (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 alpha subunits which form the PRTS gate. The two inner rings contain 6 beta subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which binds polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, ''i.e.'' the crystal structure of yeast Proteasome ([[3gpt]]). |
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== 3D Structures of Proteasome == | == 3D Structures of Proteasome == | ||
| - | 20S particle | ||
| - | + | === 20S particle === | |
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| - | 20S+activator protein | ||
| - | + | [[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br /> | |
| - | + | [[3gpt]], [[3gpw]], [[1g0u]] – y20S core - yeast<br /> | |
| - | + | [[1ryp]] - y20S core (mutant)<br /> | |
| + | [[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | ||
| + | [[3c91]], [[3c92]], [[1pma]] – Ta20S core - ''Themoplasma acidophilum''<br /> | ||
| + | [[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br /> | ||
| + | [[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br /> | ||
| + | [[1q5q]] - Re20S core<br /> | ||
| + | [[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br /> | ||
| + | [[1iru]] – 20S core - bovine<br /> | ||
| - | 20S+inhibitor | ||
| - | + | === 20S+activator protein === | |
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| - | Partial 20S | ||
| - | 2ku1, 2ku2 – Taa-PRTS chains A-G | + | [[1vsy]], [[1l5q]] – y20S core+ Blm10 <br /> |
| - | 3fp9 – MtATPase chains A-L | + | [[1z7q]], [[1fnt]] – y20S core+PA26<br /> |
| - | 1j2p – Af | + | [[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br /> |
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| + | === 20S+inhibitor === | ||
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| + | [[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3zcy]], [[3bdm]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]] – y20S core+inhibitor<br /> | ||
| + | [[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]] – Mt20S core+inhibitor<br /> | ||
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| + | === Partial 20S === | ||
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| + | [[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br /> | ||
| + | [[3fp9]] – MtATPase chains A-L<br /> | ||
| + | [[1j2p]] – Af α subunit<br /> | ||
Revision as of 15:12, 20 September 2010
Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 alpha subunits which form the PRTS gate. The two inner rings contain 6 beta subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which binds polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, i.e. the crystal structure of yeast Proteasome (3gpt).
Contents |
3D Structures of Proteasome
20S particle
3mfe, 3mi0, 2fhg – Mt20S core – Mycobacterium tuberculosis
3gpt, 3gpw, 1g0u – y20S core - yeast
1ryp - y20S core (mutant)
3mka, 3hfa – Mt20S core (mutant)
3c91, 3c92, 1pma – Ta20S core - Themoplasma acidophilum
3h4p – 20S core – Methanocaldococcus janaschii
2h6j, 1q5r – Re20S core (mutant) – Rhodococcus erythropolis
1q5q - Re20S core
1j2q – Af20S core - Archaeoglobus fulgidus
1iru – 20S core - bovine
20S+activator protein
1vsy, 1l5q – y20S core+ Blm10
1z7q, 1fnt – y20S core+PA26
3ipm, 3jrm, 3jse, 3jtl, 1ya7, 1yar, 1yau - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U
20S+inhibitor
3hye, 3gpj, 3dy3, 3dy4, 3e47, 3d29, 3zcy, 3bdm, 2gpl, 2fak, 2f16, 1jd2, 1g65 – y20S core+inhibitor
3h6f, 3h6i, 3hf9, 2fhh – Mt20S core+inhibitor
Partial 20S
2ku1, 2ku2 – Taa-PRTS chains A-G
3fp9 – MtATPase chains A-L
1j2p – Af α subunit
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
