1uw5
From Proteopedia
(New page: 200px<br /> <applet load="1uw5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uw5, resolution 2.90Å" /> '''STRUCTURE OF PITP-A...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UW5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PIE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UW5 OCA]]. | + | 1UW5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PIE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: PI1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UW5 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:00:14 2007'' |
Revision as of 08:55, 30 October 2007
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STRUCTURE OF PITP-ALPHA COMPLEXED TO PHOSPHATIDYLINOSITOL
Overview
Phosphatidylinositol transfer protein alpha (PITPalpha) selectively, transports and promotes exchange of phosphatidylinositol (PI) and, phosphatidylcholine (PC) between lipid bilayers. In higher eukaryotes, PITPalpha is required for cellular functions such as phospholipase, C-mediated signaling, regulated exocytosis, and secretory vesicle, formation. We have determined the crystal structure of human PITPalpha, bound to its physiological ligand, PI, at 2.95 A resolution. The structure, identifies the critical side chains within the lipid-headgroup binding, pocket that define the exquisite specificity for PI. Mutational analysis, of the PI binding pocket is in good agreement with the structural data and, allows manipulation of functional properties of PITPalpha. Surprisingly, there are no ... [(full description)]
About this Structure
1UW5 is a [Single protein] structure of sequence from [Homo sapiens] with PIE as [ligand]. Structure known Active Site: PI1. Full crystallographic information is available from [OCA].
Reference
Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol., Tilley SJ, Skippen A, Murray-Rust J, Swigart PM, Stewart A, Morgan CP, Cockcroft S, McDonald NQ, Structure. 2004 Feb;12(2):317-26. PMID:14962392
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