1z6e

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{{STRUCTURE_1z6e| PDB=1z6e | SCENE= }}
{{STRUCTURE_1z6e| PDB=1z6e | SCENE= }}
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===Crystal Structure of Factor Xa complexed to Razaxaban===
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===Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)===
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==About this Structure==
==About this Structure==
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1Z6E is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6E OCA].
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1Z6E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6E OCA].
==Reference==
==Reference==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Alexander, R S.]]
[[Category: Alexander, R S.]]
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[[Category: Bai, S.]]
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[[Category: Blood coagulation]]
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[[Category: Clark, C G.]]
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[[Category: Blood coagulation factor]]
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[[Category: Ellis, C D.]]
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[[Category: Calcium-binding]]
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[[Category: Han, Q.]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: He, M Y.]]
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[[Category: Disulfide bond]]
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[[Category: Knabb, R M.]]
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[[Category: Egf-like domain]]
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[[Category: Lam, P Y.S.]]
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[[Category: Glycoprotein]]
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[[Category: Li, R.]]
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[[Category: Hydrolase]]
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[[Category: Luettgen, J M.]]
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[[Category: Plasma]]
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[[Category: Pinto, D J.P.]]
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[[Category: Protein inhibitor complex]]
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[[Category: Quan, M L.]]
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[[Category: Serine protease]]
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[[Category: Sun, J H.]]
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[[Category: Teleha, C A.]]
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[[Category: Wexler, R R.]]
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[[Category: Wong, P C.]]
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[[Category: Coagulation cascade]]
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[[Category: Factor xa]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:35:12 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 07:47:10 2010''

Revision as of 04:37, 29 September 2010

Image:1z6e.png

Template:STRUCTURE 1z6e

Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)

Template:ABSTRACT PUBMED 15771420

About this Structure

1Z6E is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Quan ML, Lam PY, Han Q, Pinto DJ, He MY, Li R, Ellis CD, Clark CG, Teleha CA, Sun JH, Alexander RS, Bai S, Luettgen JM, Knabb RM, Wong PC, Wexler RR. Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. J Med Chem. 2005 Mar 24;48(6):1729-44. PMID:15771420 doi:10.1021/jm0497949

Page seeded by OCA on Wed Sep 29 07:47:10 2010

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