Fibrinogen
From Proteopedia
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<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' /> | <applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' /> | ||
| - | '''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing | + | '''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing knobs A and B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. <ref>PMID:18673233</ref> |
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
| + | <br clear="all" /> | ||
==3D Structure of Fibrinogen== | ==3D Structure of Fibrinogen== | ||
| - | Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene> ) . | + | Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>). |
===Fibrinogen alpha+beta+gamma chains=== | ===Fibrinogen alpha+beta+gamma chains=== | ||
| - | [[ | + | ==== Human ==== |
| - | [[ | + | hFba + hFbb + hFbg: |
| - | [[ | + | [[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] |
| - | + | <br /> | |
| - | [[ | + | hFba + hFbb + hFbg + knobs A & B: |
| - | [[ | + | [[3ghg]], [[2q9i]], [[2z4e]] |
| - | [[ | + | <br /> |
| - | [[1ei3]] | + | hFba + hFbb + hFbg + peptide ligand: |
| + | [[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] | ||
| + | <br /> | ||
| + | hFba + hFbb + hFbg + thrombin + PPACK thrombin inhibitor: | ||
| + | [[2a45]] | ||
| + | ==== Cow ==== | ||
| + | cFba + cFbb + cFbg: | ||
| + | [[1jy3]], [[1deq]] | ||
| + | ==== Sea lamprey ==== | ||
| + | Fba + Fbb + Fbg + peptide ligand: | ||
| + | [[1n73]], [[1lwu]] | ||
| + | ==== Hen ==== | ||
| + | heFba + heFbb + heFbg: | ||
| + | [[1ei3]] | ||
| + | <br /> | ||
| + | heFba + heFbb + heFbg + peptide ligand: | ||
| + | [[1m1j]] | ||
===Fibrinogen alpha chain=== | ===Fibrinogen alpha chain=== | ||
| - | [[ | + | cFba: [[2baf]]<br /> |
| - | [[2jor]] | + | cFba – NMR: [[2jor]]<br /> |
| - | [[ | + | hFba EC domain: [[1fzd]] <br /> |
===Fibrinogen beta chain=== | ===Fibrinogen beta chain=== | ||
| - | [[ | + | hFb fragment D: [[1fze]], [[1fza]], [[1fzb]]<br /> |
| - | [[ | + | hFb fragment double-D + peptide ligand: [[1fzf]], [[1fzg]]<br /> |
===Fibrinogen gamma chain=== | ===Fibrinogen gamma chain=== | ||
| - | [[ | + | hFbg: [[1fic]], [[1fid]] <br /> |
| - | [[ | + | hFbg + Ca: [[1fib]]<br /> |
| - | [[ | + | hFbg + peptide ligand: [[2fib]], [[3fib]] <br /> |
| - | [[ | + | hFbg + SaClumping Factor A – ''Staphylococcus aureus'': [[2vr3]]<br /> |
| - | + | hFbg + Integrin alpha IIB + Integrin beta-3 + Monoclonal antibody heavy and light chains: [[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] <br /> | |
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 11:52, 29 September 2010
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Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2]
Contents |
3D Structure of Fibrinogen
Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).
Fibrinogen alpha+beta+gamma chains
Human
hFba + hFbb + hFbg:
1re4, 1rf0, 1n8e, 1lt9
hFba + hFbb + hFbg + knobs A & B:
3ghg, 2q9i, 2z4e
hFba + hFbb + hFbg + peptide ligand:
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj
hFba + hFbb + hFbg + thrombin + PPACK thrombin inhibitor:
2a45
Cow
cFba + cFbb + cFbg: 1jy3, 1deq
Sea lamprey
Fba + Fbb + Fbg + peptide ligand: 1n73, 1lwu
Hen
heFba + heFbb + heFbg:
1ei3
heFba + heFbb + heFbg + peptide ligand:
1m1j
Fibrinogen alpha chain
cFba: 2baf
cFba – NMR: 2jor
hFba EC domain: 1fzd
Fibrinogen beta chain
hFb fragment D: 1fze, 1fza, 1fzb
hFb fragment double-D + peptide ligand: 1fzf, 1fzg
Fibrinogen gamma chain
hFbg: 1fic, 1fid
hFbg + Ca: 1fib
hFbg + peptide ligand: 2fib, 3fib
hFbg + SaClumping Factor A – Staphylococcus aureus: 2vr3
hFbg + Integrin alpha IIB + Integrin beta-3 + Monoclonal antibody heavy and light chains: 2vdo, 2vdp, 2vdq, 2vdr
References
- ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
- ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233
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