Molecular Playground/Human Galactosamine-6-sulfatase
From Proteopedia
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PPCA, is synthesized as a 542 amino acid precursor with a molecular weight of 54kDa. and it dimerizes soon after synthesis. The sequence contains two glycosylation sites, Asn 117 and Asn 305. It also contains nine cysteines. The spinning protein (<scene name='User:Yadilette_Rivera-Colon/Sandbox1/Glycosylation_sites_ppca/1'>PPCA Glycosylation sites</scene> ) is human protective protein with the glycosylation sites represented in stick model colored by atom. | PPCA, is synthesized as a 542 amino acid precursor with a molecular weight of 54kDa. and it dimerizes soon after synthesis. The sequence contains two glycosylation sites, Asn 117 and Asn 305. It also contains nine cysteines. The spinning protein (<scene name='User:Yadilette_Rivera-Colon/Sandbox1/Glycosylation_sites_ppca/1'>PPCA Glycosylation sites</scene> ) is human protective protein with the glycosylation sites represented in stick model colored by atom. | ||
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| + | ==Additional Resources== | ||
| + | For additional information, see: [[Metabolic Disorders]] | ||
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===References: === | ===References: === | ||
Revision as of 08:02, 2 October 2010
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
Contents |
Human Lysosomal Protective Protein Cathepsin A (PPCA)
The human protective protein cathepsin A forms a multi-enzyme complex with beta-galactosidase and neuraminidase in lysosomes. PPCA has so far two functions:a catalytic activity overlapping with that of Cathepsin A and a protective function towards lysosomal beta-galactosidase and neuraminidase. The stability and activity of the latter glycosidases depend on their interaction with PPCA [1].
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PPCA Glycosylation sites
PPCA, is synthesized as a 542 amino acid precursor with a molecular weight of 54kDa. and it dimerizes soon after synthesis. The sequence contains two glycosylation sites, Asn 117 and Asn 305. It also contains nine cysteines. The spinning protein ( ) is human protective protein with the glycosylation sites represented in stick model colored by atom.
Additional Resources
For additional information, see: Metabolic Disorders
References:
[1] Jackman, H. L., Morris, P. W., Deddish, P. A., Skidgel, R. A. and Erdos, E. G. (1992) J. Biol. Chem. 267, 2872-2875
Molecular Playground banner: Lysosomal Human Protective Protein Cathepsin A, a lysosomal chaperone, Nobody chaperones the chaperone. That's why it is so right for this job.
Proteopedia Page Contributors and Editors (what is this?)
Yadilette Rivera-Colon, Ralph A. Francescone III, David Canner, Lynmarie K Thompson
