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Cathepsin

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[[Image:1pbh.png|left|200px|thumb|Crystal structure wild-type human procathepsin B, [[1pbh]]]]
[[Image:1pbh.png|left|200px|thumb|Crystal structure wild-type human procathepsin B, [[1pbh]]]]
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{{STRUCTURE_1pbh| PDB=1pbh | SIZE=300| SCENE= |right|CAPTION=human procathepsin B, [[1pbh]] }}
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{{STRUCTURE_1pbh| PDB=1pbh | SIZE=300| SCENE=Cathepsin/Cv/1 |right|CAPTION=human procathepsin B, [[1pbh]] }}
[[Cathepsin]] (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, ''i.e.'' the crystal structure of wild-type human procathepsin B ([[1pbh]]).
[[Cathepsin]] (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, ''i.e.'' the crystal structure of wild-type human procathepsin B ([[1pbh]]).
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[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB - human
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[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB - human<br />
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[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 – Trypanosoma brucei
+
[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 – ''Trypanosoma brucei''<br />
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[[3k9m]] – hMCTSB+stefin A
+
[[3k9m]] – hMCTSB+stefin A<br />
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[[2ipp]], [[1huc]] – hMCTSB
+
[[2ipp]], [[1huc]] – hMCTSB<br />
-
[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin
+
[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin<br />
[[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine
[[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine
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[[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor
+
[[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor<br />
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[[1ito]], [[1qdq]] – bMCTSB +inhibitor
+
[[1ito]], [[1qdq]] – bMCTSB +inhibitor<br />
-
[[1gmy]] - bMCTSB +dipeptidyl nitrile
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[[1gmy]] - bMCTSB +dipeptidyl nitrile<br />
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[[1the]] – rMCTSB (mutant)+butanone inhibitor – rat
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[[1the]] – rMCTSB (mutant)+butanone inhibitor – rat<br />
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[[1cpj]] - rMCTSB (mutant)
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[[1cpj]] - rMCTSB (mutant)<br />
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[[1cte]] - rMCTSB+pyrimidine inhibitor
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[[1cte]] - rMCTSB+pyrimidine inhibitor<br />
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[[2djf]], [[2djg]] – hMCTSC +Gly-Phe-CHN2
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[[2djf]], [[2djg]] – hMCTSC +Gly-Phe-CHN2<br />
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[[1jqp]] – rMCTSC
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[[1jqp]] – rMCTSC<br />
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[[1k3b]] – hMCTSC
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[[1k3b]] – hMCTSC <br />
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[[1lyw]], [[1lya]] – hMCTSD
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[[1lyw]], [[1lya]] – hMCTSD <br />
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[[1lyb]] - hMCTSD+pepstatin
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[[1lyb]] - hMCTSD+pepstatin<br />
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[[1tzs]] – hMCTSE+activation peptide from CTSE
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[[1tzs]] – hMCTSE+activation peptide from CTSE<br />
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[[1m6d]] – hMCTSF+piperidine inhibitor
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[[1m6d]] – hMCTSF+piperidine inhibitor<br />
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[[1kyn]] – hMCTSG +naphthalene inhibitor
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[[1kyn]] – hMCTSG +naphthalene inhibitor<br />
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[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor
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[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br />
=== Cathepsin-H mature ===
=== Cathepsin-H mature ===
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[[1nb]]3, [[1nb5]] – pMCTSH +stefin A – pig
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[[1nb]]3, [[1nb5]] – pMCTSH +stefin A – pig<br />
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[[8pch]] - pMCTSH
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[[8pch]] - pMCTSH <br />
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[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]] – hMCTSK+ pyrimidine inhibitor
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[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]] – hMCTSK+ pyrimidine inhibitor<br />
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[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor
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[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br />
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[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate
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[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br />
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[[3c9e]] - hMCTSK + chondroitin-4-sulfate
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[[3c9e]] - hMCTSK + chondroitin-4-sulfate<br />
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[[3kwb]] - hMCTSK (mutant)+dioxo-triazine
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[[3kwb]] - hMCTSK (mutant)+dioxo-triazine<br />
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[[3kw9]] - hMCTSK +triazine
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[[3kw9]] - hMCTSK +triazine<br />
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[[1yk8]] - hMCTSK + cyanamide inhibitor
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[[1yk8]] - hMCTSK + cyanamide inhibitor<br />
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[[1yt7]] - hMCTSK + ketoamide inhibitor
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[[1yt7]] - hMCTSK + ketoamide inhibitor<br />
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[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor
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[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor<br />
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[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor
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[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor<br />
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[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]] - hMCTSK + pyrrolidine inhibitor
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[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]] - hMCTSK + pyrrolidine inhibitor<br />
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[[1snk]] - hMCTSK + norleucine inhibitor
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[[1snk]] - hMCTSK + norleucine inhibitor<br />
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[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor
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[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor<br />
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[[1q6k]] - hMCTSK+carbamate inhibitor
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[[1q6k]] - hMCTSK+carbamate inhibitor<br />
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[[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor
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[[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor<br />
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[[1au2]] - hMCTSK+ propanone inhibitor
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[[1au2]] - hMCTSK+ propanone inhibitor<br />
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[[1atk]] – hMCTSK+guanidine inhibitor
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[[1atk]] – hMCTSK+guanidine inhibitor<br />
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[[1vsn]] - hMCTSK+ inhibitor
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[[1vsn]] - hMCTSK+ inhibitor<br />
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[[2ato]] – hMCTSK+myocrisin
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[[2ato]] – hMCTSK+myocrisin<br />
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[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor
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[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br />
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[[1u9w]] - hMCTSK+imidazole inhibitor
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[[1u9w]] - hMCTSK+imidazole inhibitor<br />
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[[2ftd]] – MCTSK+azepan inhibitor – Macaca mulatta
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[[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br />
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[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit
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[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br />
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[[3f75]] – MCTSL +CTSL propeptide – Toxoplasma gondii
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[[3f75]] – MCTSL +CTSL propeptide – ''Toxoplasma gondii''<br />
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[[2p86]] – TbMCTSL +K11002
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[[2p86]] – TbMCTSL +K11002<br />
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[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – Trypanosoma cruzi
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[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – ''Trypanosoma cruzi''<br />
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[[1mhw]] – hMCTSL +tripeptide
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[[1mhw]] – hMCTSL +tripeptide<br />
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[[1icf]] – hMCTSL +MHC class II fragment
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[[1icf]] – hMCTSL +MHC class II fragment<br />
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[[2o6x]] – hPCTSL1 (mutant) – Fasciola hepatica
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[[2o6x]] – hPCTSL1 (mutant) – ''Fasciola hepatica''<br />
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[[3iv2]] – hMCTSL1 (mutant)
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[[3iv2]] – hMCTSL1 (mutant) <br />
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[[3k24]] - hMCTSL1 (mutant) +tripeptide
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[[3k24]] - hMCTSL1 (mutant) +tripeptide<br />
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[[3bc3]] - hMCTSL1 +inhibitor
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[[3bc3]] - hMCTSL1 +inhibitor<br />
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[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor
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[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor<br />
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[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor
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[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor<br />
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[[3h6s]] – hMCTSL2+clitocypin
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[[3h6s]] – hMCTSL2+clitocypin<br />
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[[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor
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[[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor<br />
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[[2c0y]] – hPCTSS (mutant)
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[[2c0y]] – hPCTSS (mutant)<br />
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[[3n3g]] - hMCTSS+ pyrimidine inhibitor
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[[3n3g]] - hMCTSS+ pyrimidine inhibitor<br />
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[[3kwn]] – hMCTSS (mutant)+ thioether acetamide
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[[3kwn]] – hMCTSS (mutant)+ thioether acetamide<br />
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[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor
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[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor<br />
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[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor
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[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor<br />
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[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor
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[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor<br />
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[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor
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[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br />
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[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor
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[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor<br />
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[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor
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[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br />
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[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor
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[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br />
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[[1glo]] - hMCTSS (mutant)
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[[1glo]] - hMCTSS (mutant)<br />
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[[1deu]] - hPCTSX
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[[1deu]] - hPCTSX<br />
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[[1ef7]] – hMCTSX
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[[1ef7]] – hMCTSX<br />

Revision as of 07:19, 13 October 2010

Image:1pbh.png
Crystal structure wild-type human procathepsin B, 1pbh

Template:STRUCTURE 1pbh

Cathepsin (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, i.e. the crystal structure of wild-type human procathepsin B (1pbh).

Contents

3D Structures of Cathepsin

Procathepsin-B

1pbh, 2pbh, 3pbh – hPCTSB - human


Cathepsin-B mature

3hhi – TbCTSB (mutant) residues 23-340+CA074 – Trypanosoma brucei
3k9m – hMCTSB+stefin A
2ipp, 1huc – hMCTSB
3cbj, 3cbk – hMCTSB (mutant)+chagasin
2dc6, 2dc7, 2dc8, 2dc9, 2dca, 2dcb, 2dcc, 2dcd – bMCTSB+inhibitor – bovine 1sp4, 1csb – bMCTSB+epoxysuccinyl inhibitor
1ito, 1qdq – bMCTSB +inhibitor
1gmy - bMCTSB +dipeptidyl nitrile
1the – rMCTSB (mutant)+butanone inhibitor – rat
1cpj - rMCTSB (mutant)
1cte - rMCTSB+pyrimidine inhibitor


Cathepsin-C mature

2djf, 2djg – hMCTSC +Gly-Phe-CHN2
1jqp – rMCTSC
1k3b – hMCTSC


Cathepsin-D mature

1lyw, 1lya – hMCTSD
1lyb - hMCTSD+pepstatin


Cathepsin-E mature

1tzs – hMCTSE+activation peptide from CTSE


Cathepsin-F mature

1m6d – hMCTSF+piperidine inhibitor


Cathepsin-G mature

1kyn – hMCTSG +naphthalene inhibitor
1au8, 1cgh - hMCTSG +phosphonate inhibitor


Cathepsin-H mature

1nb3, 1nb5 – pMCTSH +stefin A – pig
8pch - pMCTSH


Cathepsin-K mature

3o1g, 3n3g, 2r6n, 1bgo, 3kwz, 3kx1 – hMCTSK+ pyrimidine inhibitor
3mpe, 3mpf – hMCTSK (mutant) + pyrimidine inhibitor
3h7d - hMCTSK (mutant) + chondroitin-4-sulfate
3c9e - hMCTSK + chondroitin-4-sulfate
3kwb - hMCTSK (mutant)+dioxo-triazine
3kw9 - hMCTSK +triazine
1yk8 - hMCTSK + cyanamide inhibitor
1yt7 - hMCTSK + ketoamide inhibitor
2aux, 2auz - hMCTSK + semicarbazone inhibitor
1ayu, 1ayv, 1ayw - hMCTSK + carbohydrazide inhibitor
2bdl, 1yk7, 1tu6, 1au3, 1au4 - hMCTSK + pyrrolidine inhibitor
1snk - hMCTSK + norleucine inhibitor
1nl6, 1nlj - hMCTSK+ azepanone inhibitor
1q6k - hMCTSK+carbamate inhibitor
1au0 - hMCTSK+ diacylaminoethyl ketone inhibitor
1au2 - hMCTSK+ propanone inhibitor
1atk – hMCTSK+guanidine inhibitor
1vsn - hMCTSK+ inhibitor
2ato – hMCTSK+myocrisin
1u9v, 1u9x, 1mem – hMCTSK+piperazine inhibitor
1u9w - hMCTSK+imidazole inhibitor
2ftd – MCTSK+azepan inhibitor – Macaca mulatta
2f7d – MCTSK (mutant)+nitrile inhibitor - rabbit


Cathepsin-L mature

3f75 – MCTSL +CTSL propeptide – Toxoplasma gondii
2p86 – TbMCTSL +K11002
2nqd - CTSL residues 1-220 (mutant)+chagasin – Trypanosoma cruzi
1mhw – hMCTSL +tripeptide
1icf – hMCTSL +MHC class II fragment


Procathepsin-L1

2o6x – hPCTSL1 (mutant) – Fasciola hepatica


Cathepsin-L1 mature

3iv2 – hMCTSL1 (mutant)
3k24 - hMCTSL1 (mutant) +tripeptide
3bc3 - hMCTSL1 +inhibitor
3h89, 3h8b, 3h8c - hMCTSL1 (mutant) + retro-binding inhibitor
3hwn, 3hha – hMCTSL1+pyrazole inhibitor


Cathepsin-L2 mature

3h6s – hMCTSL2+clitocypin
1fh0 – hMCTSL2 (mutant) +vinyl sulfone inhibitor


Procathepsin-S

2c0y – hPCTSS (mutant)


Cathepsin-S mature

3n3g - hMCTSS+ pyrimidine inhibitor
3kwn – hMCTSS (mutant)+ thioether acetamide
3iej - hMCTSS (mutant)+pyrazole inhibitor
2h7j, 2hxz- hMCTSS+triazole inhibitor
2r9m, 2r9n, 2r9o – hMCTSS+piperidine inhibitor
2op3, 2hhn, 2g7y, 2hh5, 2f1g – hMCTSS+aryl inhibitor
2fud, 2fra, 2frq, 2ft2, 1npz, 1nqc – hMCTSS+inhibitor
2fye, 2g6d – hMCTSS (mutant)+inhibitor
2fq9, 1ms6 – hMCTSS +nitrile inhibitor
1glo - hMCTSS (mutant)


Procathepsin-X

1deu - hPCTSX


Cathepsin-X mature

1ef7 – hMCTSX

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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