1e7z
From Proteopedia
(New page: 200px<br /> <applet load="1e7z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e7z, resolution 2.05Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1E7Z is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with HG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E7Z OCA]]. | + | 1E7Z is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with HG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: HG1 and HG2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E7Z OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: trna synthetase complex]] | [[Category: trna synthetase complex]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:03:46 2007'' |
Revision as of 08:59, 30 October 2007
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CRYSTAL STRUCTURE OF THE EMAP2/RNA BINDING DOMAIN OF THE P43 PROTEIN FROM HUMAN AMINOACYL-TRNA SYNTHETASE COMPLEX
Overview
The EMAPII (endothelial monocyte-activating polypeptide II) domain is a, tRNA-binding domain associated with several aminoacyl-tRNA synthetases, which becomes an independent domain with inflammatory cytokine activity, upon apoptotic cleavage from the p43 component of the multisynthetase, complex. It comprises a domain that is highly homologous to bacterial, tRNA-binding proteins (Trbp), followed by an extra domain without homology, to known proteins. Trbps, which may represent ancient tRNA chaperones, form dimers and bind one tRNA per dimer. In contrast, EMAPII domains are, monomers. Here we report the crystal structure at 1.14 Angstroms of human, EMAPII. The structure reveals that the Trbp-like domain, which forms an, oligonucleotide-binding (OB) fold, is related by degenerate 2-fold, ... [(full description)]
About this Structure
1E7Z is a [Single protein] structure of sequence from [Homo sapiens] with HG as [ligand]. Structure known Active Sites: HG1 and HG2. Full crystallographic information is available from [OCA].
Reference
Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry., Renault L, Kerjan P, Pasqualato S, Menetrey J, Robinson JC, Kawaguchi S, Vassylyev DG, Yokoyama S, Mirande M, Cherfils J, EMBO J. 2001 Feb 1;20(3):570-8. PMID:11157763
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