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2zb1
From Proteopedia
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(New page: 200px<br /><applet load="2zb1" size="350" color="white" frame="true" align="right" spinBox="true" caption="2zb1, resolution 2.500Å" /> '''Crystal structure o...)
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Revision as of 09:10, 23 January 2008
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Crystal structure of P38 in complex with biphenyl amide inhibitor
Overview
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase, inhibitors. The discovery of the series through structure-based focused, screening is described, and the binding mode of the compounds is explained, with reference to X-ray crystal structures.
About this Structure
2ZB1 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.
Reference
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306
Page seeded by OCA on Wed Jan 23 11:10:42 2008
