2eb7

From Proteopedia

---

Revision as of 09:12, 23 January 2008

proteopedia linkproteopedia link

spinqualitylabelsall models 2eb7, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7

Overview

The emergence of bacterial resistance to multiple drugs poses a serious, and growing health concern. Understanding and deciphering the mechanisms, of these multiple drug resistance regulatory proteins through structural, or biochemical means is an important endeavor. Here, we present the, crystal structure of ST1710 from Sulfolobus tokodaii strain 7 in two, different crystal forms, at 1.80 and 2.0A, respectively. The overall, structure of the ST1710 dimer shares the topology of the MarR family of, proteins, with each subunit containing a winged helix-turn-helix, DNA-binding motif. We also show the protein-DNA interactions by, biochemical methods. Our molecular modeling analysis suggested that Asp88, and Arg90 are the key residues in ST1710 involved in the protein-DNA, interactions.

About this Structure

2EB7 is a Single protein structure of sequence from Sulfolobus tokodaii. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MarR family regulatory protein, ST1710, from Sulfolobus tokodaii strain 7., Kumarevel T, Tanaka T, Nishio M, Gopinath SC, Takio K, Shinkai A, Kumar PK, Yokoyama S, J Struct Biol. 2007 Sep 8;. PMID:17933554

Page seeded by OCA on Wed Jan 23 11:12:32 2008