3bib
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(New page: 200px<br /><applet load="3bib" size="350" color="white" frame="true" align="right" spinBox="true" caption="3bib, resolution 2.50Å" /> '''Tim-4 in complex wit...)
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Revision as of 09:21, 23 January 2008
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Tim-4 in complex with phosphatidylserine
Overview
The T cell immunoglobulin and mucin domain (TIM) proteins are important, regulators of T cell responses. Crystal structures of the murine TIM-4, identified a metal-ion-dependent ligand binding site (MILIBS) in the, immunoglobulin (Ig) domain of the TIM family. The characteristic CC' loop, of the TIM domain and the hydrophobic FG loop shaped a narrow cavity where, acidic compounds penetrate and coordinate to a metal ion bound to, conserved residues in the TIM proteins. The structure of, phosphatidylserine bound to the Ig domain showed that the hydrophilic head, penetrates into the MILIBS and coordinates with the metal ion, whereas the, aromatic residues on the tip of the FG loop interacted with the fatty acid, chains and could insert into the lipid bilayer. Our results also revealed, an important role of the MILIBS in the trafficking of TIM-1 to the cell, surface.
About this Structure
3BIB is a Single protein structure of sequence from Mus musculus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds., Santiago C, Ballesteros A, Martinez-Munoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM, Immunity. 2007 Dec;27(6):941-51. PMID:18083575
Page seeded by OCA on Wed Jan 23 11:21:23 2008
