2o5n
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="2o5n" size="350" color="white" frame="true" align="right" spinBox="true" caption="2o5n, resolution 2.400Å" /> '''Crystal structure o...)
Next diff →
Revision as of 09:22, 23 January 2008
|
Crystal structure of a Viral Glycoprotein
Overview
Mouse cytomegalovirus (MCMV), a ss-herpesvirus that establishes latent and, persistent infections in mice, is a valuable model for studying complex, virus-host interactions. MCMV encodes the m145 family of putative, immunoevasins with predicted MHC-I structure. Functions attributed to some, family members include downregulation of host MHC-I (m152) and NKG2D, ligands (m145, m152, m155) and interaction with inhibitory or activating, NK receptors (m157). We present the cellular, biochemical and structural, characterization of m153, which is a heavily glycosylated homodimer, that, does not require ss2m or peptide, and is expressed at the surface of, MCMV-infected cells. Its 2.4 A crystal structure confirms that this, compact molecule preserves an MHC-I-like fold and reveals a novel mode of, dimerization, confirmed by site-directed mutagenesis, and a distinctive, disulfide-stabilized extended amino terminus. The structure provides a, useful framework for comparative analysis of the divergent members of the, m145 family.
About this Structure
2O5N is a Protein complex structure of sequences from Murid herpesvirus 1 with as ligand. Full crystallographic information is available from OCA.
Reference
Cellular expression and crystal structure of the murine cytomegalovirus MHC-Iv glycoprotein, m153., Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, Robinson H, Simic H, Jonjic S, Tiemessen CT, Margulies DH, J Biol Chem. 2007 Sep 26;. PMID:17897947
Page seeded by OCA on Wed Jan 23 11:22:55 2008
