Phosphoinositide 3-Kinases
From Proteopedia
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<scene name='User:David_Canner/Sandbox_P/Inhibitor_myrice/1'>Myricetin</scene> | <scene name='User:David_Canner/Sandbox_P/Inhibitor_myrice/1'>Myricetin</scene> | ||
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| + | ==Additional 3D Structures== | ||
| + | The Following are Solved Structures of PI3K. <br /> | ||
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| + | ===Class I PI3K=== | ||
| + | ====PI3K SH2 Domain==== | ||
| + | [[2iug]], [[2iuh]], [[2iui]] – Crystal Structure of PI3K nSH2 Domain with Peptides <br/> | ||
| + | [[1h9o]] – Crystal Structure of PI3K SH2 Domain with PDGFR Peptide <br /> | ||
| + | [[1fu5]], [[1fu6]] – NMR structure of nSH2 Domain from PI3K <br /> | ||
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| + | ====PI3K ISH2 Domain==== | ||
| + | [[3mtt]] – Crystal Structure of PI3K ISH2 Beta Crystal <br /> | ||
| + | [[3l4q]] – Crystal Structure of PI3K ISH2 in Influenza <br /> | ||
| + | [[2v1y]] – Crystal Structure of ISH2 in complex with ADB <br /> | ||
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| + | ====PI3K SH3 Domain==== | ||
| + | [[3i5s]], [[3i5r]] – Crystal Structure of SH3 Domain in complex with peptide <br /> | ||
| + | [[2kt1]] – Crystal Structure of SH3 Domain in p85 beta <br /> | ||
| + | [[1pht]] – Crystal Structure of PI3K Alpha SH3 Domain <br /> | ||
| + | [[1pks]], [[1pkt]] – Crystal Structure of PI3K SH3 Domain <br /> | ||
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| + | ====p110 Subunit of PI3K==== | ||
| + | [[3lj3]] – Crystal Structure of PI3K Gamma bound to Pyrrolopyridine-Benzofuran Inhibitor <br /> | ||
| + | [[3l54]] – Crystal Structure of PI3K Gamma <br /> | ||
| + | [[3l13]], [[3l16]], [[3l17]] – Crystal Structure of Pan-PI3-Kinase with Inhibitor <br /> | ||
| + | [[3l08]] – Crystal Structure of PI3K Gamma bound to GSK2126458 <br /> | ||
| + | [[3ibe]] – Crystal Structure of PI3K Gamma bound to Pyrazolopyrimidine Inhibitor <br /> | ||
| + | [[3hhm]], [[3hiz]] – Crystal Structure of p110 & NISH2 <br /> | ||
| + | [[3ene]] – Crystal Structure of PI3K Gamma with inhibitor <br /> | ||
| + | [[3dpd]] – Crystal Structure of PI3K with oxazines inhibitor <br /> | ||
| + | [[3dbs]] – Crystal Structure of PI3K Gamma bound to GDC0941 <br/ > | ||
| + | [[3csf]], [[3cst]] – Crystal Structure of p110 Gamma bound to organourethenium inhibitor <br /> | ||
| + | [[2x38]] – Crystal Structure of p110 Delta bound to IC87114 <br /> | ||
| + | [[2wxf]], [[2wxg]], [[2wxh]], [[2wxi]], [[2wxj]], [[2wxk]], [[2wxl]], [[2wxm]], [[2wxn]], [[2wxo]], [[2wxp]], [[2wxq]], [[2wxr]] – Crystal Structure of p110 Delta with Inhibitors <br /> | ||
| + | [[2v4l]] – Crystal Structure of PI3K p110 Gamma with inhibitor <br /> | ||
| + | [[2rd0]] – Crystal Structure of PI3K p110/p85 complex <br /> | ||
| + | [[2chw]], [[2chx]], [[2chz]] – Crystal Structure of PI3K Gamma with PIK-39 Inhibitor <br/ > | ||
| + | [[2a4z]], [[2a5u]] – Crystal Structure of PI3K gamma complex with AS604850 and AS605240 Inhibitors <br /> | ||
| + | [[1he8]] – Crystal Structure of RAS – PI3K Gamma Complex <br /> | ||
| + | [[1e7u]], [[1e7v]], [[1e7w]], [[1e7y]], [[1e7z]], [[1e90]], [[1e8x]] – Crystal Structure of PI3K Bound to Various Inhibitors <br /> | ||
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| + | ====PI3K C2 Domain==== | ||
| + | [[2wwe]] – Crystal Structure of PI3K C2 Gamma Domain <br /> | ||
| + | [[2enq]] – Crystal Structure of C2 Domain, p110 Alpha <br /> | ||
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| + | ===Class III PI3K=== | ||
| + | [[2x6f]], [[2x6h]], [[2x6j]], [[2x6k]] – Crystal Structure of Class III PI3K bound to various inhibitors <br /> | ||
| + | [[3ls8]] – Crystal Structure of Class III PI3K in complex with inhibitor <br /> | ||
| + | [[3ihy]] – Crystal Structure of Human PI3K Class III <br/> | ||
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| + | ==Additional Resources== | ||
| + | * See: [[Cancer]] For Additional Proteins involved in the disease. <br /> | ||
| + | * See: [[Oncogenes]] for Additional examples of oncogenes and tumor suppressor genes. | ||
| + | <br /> | ||
Revision as of 08:06, 3 November 2010
Contents |
Additional 3D Structures
The Following are Solved Structures of PI3K.
Class I PI3K
PI3K SH2 Domain
2iug, 2iuh, 2iui – Crystal Structure of PI3K nSH2 Domain with Peptides
1h9o – Crystal Structure of PI3K SH2 Domain with PDGFR Peptide
1fu5, 1fu6 – NMR structure of nSH2 Domain from PI3K
PI3K ISH2 Domain
3mtt – Crystal Structure of PI3K ISH2 Beta Crystal
3l4q – Crystal Structure of PI3K ISH2 in Influenza
2v1y – Crystal Structure of ISH2 in complex with ADB
PI3K SH3 Domain
3i5s, 3i5r – Crystal Structure of SH3 Domain in complex with peptide
2kt1 – Crystal Structure of SH3 Domain in p85 beta
1pht – Crystal Structure of PI3K Alpha SH3 Domain
1pks, 1pkt – Crystal Structure of PI3K SH3 Domain
p110 Subunit of PI3K
3lj3 – Crystal Structure of PI3K Gamma bound to Pyrrolopyridine-Benzofuran Inhibitor
3l54 – Crystal Structure of PI3K Gamma
3l13, 3l16, 3l17 – Crystal Structure of Pan-PI3-Kinase with Inhibitor
3l08 – Crystal Structure of PI3K Gamma bound to GSK2126458
3ibe – Crystal Structure of PI3K Gamma bound to Pyrazolopyrimidine Inhibitor
3hhm, 3hiz – Crystal Structure of p110 & NISH2
3ene – Crystal Structure of PI3K Gamma with inhibitor
3dpd – Crystal Structure of PI3K with oxazines inhibitor
3dbs – Crystal Structure of PI3K Gamma bound to GDC0941
3csf, 3cst – Crystal Structure of p110 Gamma bound to organourethenium inhibitor
2x38 – Crystal Structure of p110 Delta bound to IC87114
2wxf, 2wxg, 2wxh, 2wxi, 2wxj, 2wxk, 2wxl, 2wxm, 2wxn, 2wxo, 2wxp, 2wxq, 2wxr – Crystal Structure of p110 Delta with Inhibitors
2v4l – Crystal Structure of PI3K p110 Gamma with inhibitor
2rd0 – Crystal Structure of PI3K p110/p85 complex
2chw, 2chx, 2chz – Crystal Structure of PI3K Gamma with PIK-39 Inhibitor
2a4z, 2a5u – Crystal Structure of PI3K gamma complex with AS604850 and AS605240 Inhibitors
1he8 – Crystal Structure of RAS – PI3K Gamma Complex
1e7u, 1e7v, 1e7w, 1e7y, 1e7z, 1e90, 1e8x – Crystal Structure of PI3K Bound to Various Inhibitors
PI3K C2 Domain
2wwe – Crystal Structure of PI3K C2 Gamma Domain
2enq – Crystal Structure of C2 Domain, p110 Alpha
Class III PI3K
2x6f, 2x6h, 2x6j, 2x6k – Crystal Structure of Class III PI3K bound to various inhibitors
3ls8 – Crystal Structure of Class III PI3K in complex with inhibitor
3ihy – Crystal Structure of Human PI3K Class III
Additional Resources
- See: Cancer For Additional Proteins involved in the disease.
- See: Oncogenes for Additional examples of oncogenes and tumor suppressor genes.
Proteopedia Page Contributors and Editors (what is this?)
David Canner, Michal Harel, Joel L. Sussman, Jaime Prilusky, Hannah Campbell, Alexander Berchansky, Angel Herraez
