1h1v
From Proteopedia
(New page: 200px<br /> <applet load="1h1v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h1v, resolution 2.99Å" /> '''GELSOLIN G4-G6/ACTI...) |
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caption="1h1v, resolution 2.99Å" /> | caption="1h1v, resolution 2.99Å" /> | ||
'''GELSOLIN G4-G6/ACTIN COMPLEX'''<br /> | '''GELSOLIN G4-G6/ACTIN COMPLEX'''<br /> | ||
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| + | ==Overview== | ||
| + | Gelsolin participates in the reorganization of the actin cytoskeleton that, is required during such phenomena as cell movement, cytokinesis, and, apoptosis. It consists of six structurally similar domains, G1-G6, which, are arranged at resting intracellular levels of calcium ion so as to, obscure the three actin-binding surfaces. Elevation of Ca(2+), concentrations releases latches within the constrained structure and, produces large shifts in the relative positioning of the domains, permitting gelsolin to bind to and sever actin filaments. How Ca(2+) is, able to activate gelsolin has been a major question concerning the, function of this protein. We present the improved structure of the, C-terminal half of gelsolin bound to monomeric actin at 3.0 A resolution., Two classes of ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12460571 (full description)]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 1H1V is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]] with CA and ATP as [[http://en.wikipedia.org/wiki/ligands ligands]]. This structure superseeds the now removed PDB entry 1DB0. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H1V OCA]]. | + | 1H1V is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]] with CA and ATP as [[http://en.wikipedia.org/wiki/ligands ligands]]. This structure superseeds the now removed PDB entry 1DB0. Structure known Active Site: CA1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H1V OCA]]. |
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| + | ==Reference== | ||
| + | The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex., Choe H, Burtnick LD, Mejillano M, Yin HL, Robinson RC, Choe S, J Mol Biol. 2002 Dec 6;324(4):691-702. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12460571 12460571] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
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[[Category: severing]] | [[Category: severing]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:07:33 2007'' |
Revision as of 09:02, 30 October 2007
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GELSOLIN G4-G6/ACTIN COMPLEX
Overview
Gelsolin participates in the reorganization of the actin cytoskeleton that, is required during such phenomena as cell movement, cytokinesis, and, apoptosis. It consists of six structurally similar domains, G1-G6, which, are arranged at resting intracellular levels of calcium ion so as to, obscure the three actin-binding surfaces. Elevation of Ca(2+), concentrations releases latches within the constrained structure and, produces large shifts in the relative positioning of the domains, permitting gelsolin to bind to and sever actin filaments. How Ca(2+) is, able to activate gelsolin has been a major question concerning the, function of this protein. We present the improved structure of the, C-terminal half of gelsolin bound to monomeric actin at 3.0 A resolution., Two classes of ... [(full description)]
About this Structure
1H1V is a [Protein complex] structure of sequences from [Homo sapiens] and [Oryctolagus cuniculus] with CA and ATP as [ligands]. This structure superseeds the now removed PDB entry 1DB0. Structure known Active Site: CA1. Full crystallographic information is available from [OCA].
Reference
The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex., Choe H, Burtnick LD, Mejillano M, Yin HL, Robinson RC, Choe S, J Mol Biol. 2002 Dec 6;324(4):691-702. PMID:12460571
Page seeded by OCA on Tue Oct 30 11:07:33 2007
Categories: Homo sapiens | Oryctolagus cuniculus | Protein complex | Burtnick, L.D. | Choe, H. | Choe, S. | Mejillano, M. | Robinson, R.C. | Yin, H.L. | ATP | CA | Actin-binding | Amyloid | Calcium | Capping | Muscle contraction | Severing
