1h1t
From Proteopedia
(New page: 200px<br /> <applet load="1h1t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h1t, resolution 1.78Å" /> '''PHOSPHOPANTETHEINE ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H1T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with SO4, COA and PNS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H1T OCA]]. | + | 1H1T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with SO4, COA and PNS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3]]. Structure known Active Site: COA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H1T OCA]]. |
==Reference== | ==Reference== | ||
A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A., Izard T, J Bacteriol. 2003 Jul;185(14):4074-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12837781 12837781] | A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A., Izard T, J Bacteriol. 2003 Jul;185(14):4074-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12837781 12837781] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| + | [[Category: Pantetheine-phosphate adenylyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Izard, T.]] | [[Category: Izard, T.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:07:44 2007'' |
Revision as of 09:03, 30 October 2007
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PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE IN COMPLEX WITH COENZYME A FROM ESCHERICHIA COLI
Overview
Phosphopantetheine adenylyltransferase (PPAT) regulates the key, penultimate step in the essential coenzyme A (CoA) biosynthetic pathway., PPAT catalyzes the reversible transfer of an adenylyl group from, Mg(2+):ATP to 4'-phosphopantetheine to form 3'-dephospho-CoA (dPCoA) and, pyrophosphate. The high-resolution crystal structure of PPAT complexed, with CoA has been determined. Remarkably, CoA and the product dPCoA bind, to the active site in distinct ways. Although the phosphate moiety within, the phosphopantetheine arm overlaps, the pantetheine arm binds to the same, pocket in two distinct conformations, and the adenylyl moieties of these, two ligands have distinct binding sites. Moreover, the PPAT:CoA crystal, structure confirms the asymmetry of binding to the two trimers within the, ... [(full description)]
About this Structure
1H1T is a [Single protein] structure of sequence from [Escherichia coli] with SO4, COA and PNS as [ligands]. Active as [Pantetheine-phosphate adenylyltransferase], with EC number [2.7.7.3]. Structure known Active Site: COA. Full crystallographic information is available from [OCA].
Reference
A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A., Izard T, J Bacteriol. 2003 Jul;185(14):4074-80. PMID:12837781
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