AZT-resistant HIV-1 reverse transcriptase
From Proteopedia
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==Role of Reverse Transcriptase in HIV Replication== | ==Role of Reverse Transcriptase in HIV Replication== | ||
| - | Reverse | + | Reverse transcriptase allows Human Immunodeficiency Virus (HIV) to create DNA from its RNA. The creation of DNA allows HIV to incorporate its genetic information into the genome of the host cell. Reverse transcriptase has two enzymatic activities: DNA polymerase and RNase H. DNA polymerase is necessary for copying a DNA or RNA template, while RNase H cleaves the RNA that is part of the DNA/RNA duplex. These two activities combine to convert RNA into linear, double-stranded DNA. This DNA is then incorporated in the host's genome. The DNA created by reverse transcriptase can then be copied by host polymerase in order to make more copies of the viral genome. |
==Structure of Reverse Transcriptase== | ==Structure of Reverse Transcriptase== | ||
Revision as of 22:35, 4 November 2010
Contents |
Role of Reverse Transcriptase in HIV Replication
Reverse transcriptase allows Human Immunodeficiency Virus (HIV) to create DNA from its RNA. The creation of DNA allows HIV to incorporate its genetic information into the genome of the host cell. Reverse transcriptase has two enzymatic activities: DNA polymerase and RNase H. DNA polymerase is necessary for copying a DNA or RNA template, while RNase H cleaves the RNA that is part of the DNA/RNA duplex. These two activities combine to convert RNA into linear, double-stranded DNA. This DNA is then incorporated in the host's genome. The DNA created by reverse transcriptase can then be copied by host polymerase in order to make more copies of the viral genome.
Structure of Reverse Transcriptase
Reverse transcriptase is a heterodimer of two related subunits: p66 and p51.
Inhibition of Reverse Transcriptase Activity
AZT Resistance
Proteopedia Page Contributors and Editors (what is this?)
Alexandra Clement, David Canner, Michal Harel, Alexander Berchansky
