2rjc
From Proteopedia
(New page: 200px<br /> <applet load="2rjc" size="450" color="white" frame="true" align="right" spinBox="true" caption="2rjc, resolution 2.00Å" /> '''Crystal structure o...) |
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- | [[Image:2rjc.gif|left|200px]]<br /> | + | [[Image:2rjc.gif|left|200px]]<br /><applet load="2rjc" size="350" color="white" frame="true" align="right" spinBox="true" |
- | <applet load="2rjc" size=" | + | |
caption="2rjc, resolution 2.00Å" /> | caption="2rjc, resolution 2.00Å" /> | ||
'''Crystal structure of L3MBTL1 protein in complex with MES'''<br /> | '''Crystal structure of L3MBTL1 protein in complex with MES'''<br /> | ||
+ | |||
+ | ==Overview== | ||
+ | Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4, peptides dimethylated on Lys20 (H4K20me2) show that only the second of the, three MBT repeats can bind mono- and dimethylated histone peptides. Its, binding pocket has similarities to that of 53BP1 and is able to recognize, the degree of histone lysine methylation. An unexpected mode of, peptide-mediated dimerization suggests a possible mechanism for chromatin, compaction by L3MBTL1. | ||
==About this Structure== | ==About this Structure== | ||
- | 2RJC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and MES as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2RJC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. |
+ | |||
+ | ==Reference== | ||
+ | L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, Mackenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Nov 18;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18026117 18026117] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
- | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:32:04 2008'' |
Revision as of 09:32, 23 January 2008
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Crystal structure of L3MBTL1 protein in complex with MES
Overview
Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4, peptides dimethylated on Lys20 (H4K20me2) show that only the second of the, three MBT repeats can bind mono- and dimethylated histone peptides. Its, binding pocket has similarities to that of 53BP1 and is able to recognize, the degree of histone lysine methylation. An unexpected mode of, peptide-mediated dimerization suggests a possible mechanism for chromatin, compaction by L3MBTL1.
About this Structure
2RJC is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, Mackenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Nov 18;. PMID:18026117
Page seeded by OCA on Wed Jan 23 11:32:04 2008
Categories: Homo sapiens | Single protein | Allali-Hassani, A. | Arrowsmith, C.H. | Bochkarev, A. | Crombet, L. | Edwards, A.M. | Herzanych, N. | Kozieradzki, I. | Liu, Y. | Loppnau, P. | Mackenzie, F. | Min, J.R. | Ouyang, H. | SGC, Structural.Genomics.Consortium. | Sundstrom, M. | Vedadi, M. | Weigelt, J. | MES | SO4 | Alternative splicing | Chromatin regulator | Dna-binding | L(3)mbt-like protein | Metal-binding | Nucleus | Repressor | Sgc | Structural genomics | Structural genomics consortium | Transcription | Transcription regulation | Zinc | Zinc-finger