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Ribosomal protein L2
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[[Image:RPL2.png|left|200px|thumb|Crystal Structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D)]] | [[Image:RPL2.png|left|200px|thumb|Crystal Structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D)]] | ||
| - | {{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| SCENE= |right|CAPTION=Ribosomal protein L2 from ''Thermus thermophilus'' [[2xg0]], chain D }} | + | {{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| SCENE=Ribosomal_protein_L2/Cv/1 |right|CAPTION=Ribosomal protein L2 from ''Thermus thermophilus'' [[2xg0]], chain D }} |
| - | Ribosomal protein L2 (RPL2) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is required for the association of the 30S and 50S subunits and is involved in the binding of tRNA at the A- and P-sites. In the archaea like in ''Haloarcula marismortui'', the L2 is called L2P (RPL2P). The images at the left and at the right correspond to one representative RPL2, ''i.e.'' the crystal structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D). | + | Ribosomal protein L2 (RPL2) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L2/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is required for the association of the 30S and 50S subunits and is involved in the binding of tRNA at the A- and P-sites. In the archaea like in ''Haloarcula marismortui'', the L2 is called L2P (RPL2P). The images at the left and at the right correspond to one representative RPL2, ''i.e.'' the crystal structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D). |
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Revision as of 11:26, 11 November 2010
Ribosomal protein L2 (RPL2) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is required for the association of the 30S and 50S subunits and is involved in the binding of tRNA at the A- and P-sites. In the archaea like in Haloarcula marismortui, the L2 is called L2P (RPL2P). The images at the left and at the right correspond to one representative RPL2, i.e. the crystal structure of Ribosomal protein L2 from Thermus thermophilus (2xg0, chain D).
3D Structures of Ribosomal protein L2
RPL2
1rl2 – RPL2 – Geobacillus stearothermophilus
L2 in 50S subunit+RNA
2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL2 in 50S subunit+RNA fragments – Thermus thermophilus
2x9s, 2x9u, 3kni, 3knk, 3knm, 3kno, 2wrj, 2wrl, 2wro, 2wrr, 3hux, 3huz, 2wh2, 2wh4, 2wdi, 2wdj, 2wdl, 2wdn, 1vsp, 2v47, 2v49, 1vsa, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 3mrz, 3ms1, 3i8f, 3i8i, 3i9c, 3i9e, 3f1f, 3f1h, 3d5b, 3d5d, 2b66, 2b9n, 2b9p, 1giy - TtRPL2 in 50S subunit+5S RRNA+23S RRNA
3fin - TtRPL2 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
2wwq – EcRPL2 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli
3i1n, 3i1p, 3i1r, 3i1t, 3i20, 3i22, 3e1b, 3e1d, 3df2, 3df4, 2vhn, 2qov, 2qox, 2i2t, 2i2v, 1vs6, 1vs8, 2aw4, 2awb, 3ofd, 3og0 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA
3fik, 2gya, 2gyc, 3bbx, 1p85, 1p86 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
3kcr - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase
2rdo - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM
3bbo - RPL2 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach
3iy9 – RPL2 in 50S subunit – Leishmania taretolae
2zjq, 2zjr - DrRPL2 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans
1kqs, 1qvg - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui
1jj2, 1ffk, 3cc2, 2qa4, 1s72 - HmRPL2P in 50S subunit+5S RRNA+23S RRNA
3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL2P in 50S subunit+5S RRNA+23S RRNA (mutant)
1vq4, 1vq5, 1vq7, 1vql, 1vqm, 1vqp - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+transition state analog
1vq6, 1vqk, 1vqn - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin
1vqo - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ CCPMN
1yhq, 1yi2, 1yij, 1yjn, 1yjw - HmRPL2P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic
1yj9 - HmRPL2P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA
1qvf - HmRPL2P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix
1q86 - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin
L2 in 50S subunit + antibiotics
3cxc – RPL2 in 50S subunit+5S RRNA+23S RRNA+oxazolidinone inhibitor – Halobacterium marismortui
3dll - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+oxazolidinone inhibitor
2zjp - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+nosiheptide
3cf5 - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiostrepton
1xbp - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiamulin
1sm1 - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+quinupristin+dalfopristin
1nwx - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+ABT-773
1nwy - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+azithromycin
3oh5, 3oh7 - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol
3ohj, 3ohk - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+erythromycin
3ohz, 3oi1 - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+azithromycin
3oi3, 3oi5 - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+telithromycin
2qam, 2qao, 2qoz, 2qp1 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+neomycin
2qba, 2qbc - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+gentamicin
3ofc - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol
3ofz - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+clindamycin
3ofq, 3ofr - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+erythromycin
1vt2, 3orb - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+CEM-101
1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw, 3cc4, 3cd6, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+antibiotics
1m90, 3cma, 3cme, 1vq8, 1vq9 - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
L2 in 60S subunit
3jyw - RPL2 in 60S subunit – Thermomyces lanuginosus – Cryo-EM
2ftc - RPL2 in 60S subunit+16S RRNA - bovine
1s1i - yRPL2 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast
L2 in part of the large ribosomal subunit
487d – RPL2+RPL1+RPL6+RPL9+RPL11+RPL14+RPL25 - Cryo-EM
1c04 – HmRPL2P+RPL6+RPL11+RPS14+23S RRNA fragment
L2 in large + small ribosomal subunit
1ml5 - EcRPL2 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM
L2 in 50S subunit + ribosome releasing factor (RRF)
2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+RRF
L2 in 50S subunit + various proteins
2vhm - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix
2j28 - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM
1vor, 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc
1nkw - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc
1w2b - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
