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-	.	+	.1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
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		+	Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
		+	It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
		+
		+	Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).

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Revision as of 20:30, 16 November 2010

.1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).