2pav
From Proteopedia
(New page: 200px<br /> <applet load="2pav" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pav, resolution 1.800Å" /> '''Ternary complex of...) |
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| - | [[Image:2pav. | + | [[Image:2pav.jpg|left|200px]]<br /><applet load="2pav" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2pav, resolution 1.800Å" /> | caption="2pav, resolution 1.800Å" /> | ||
'''Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP'''<br /> | '''Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2PAV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with CA and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2PAV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PAV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: vasp]] | [[Category: vasp]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:40:05 2008'' |
Revision as of 09:40, 23 January 2008
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Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP
Overview
Cells sustain high rates of actin filament elongation by maintaining a, large pool of actin monomers above the critical concentration for, polymerization. Profilin-actin complexes constitute the largest fraction, of polymerization-competent actin monomers. Filament elongation factors, such as Ena/VASP and formin catalyze the transition of profilin-actin from, the cellular pool onto the barbed end of growing filaments. The molecular, bases of this process are poorly understood. Here we present structural, and energetic evidence for two consecutive steps of the elongation, mechanism: the recruitment of profilin-actin by the last poly-Pro segment, of vasodilator-stimulated phosphoprotein (VASP) and the binding of, profilin-actin simultaneously to this poly-Pro and to the G-actin-binding, (GAB) domain of VASP. The actin monomer bound at the GAB domain is, proposed to be in position to join the barbed end of the growing filament, concurrently with the release of profilin.
About this Structure
2PAV is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP., Ferron F, Rebowski G, Lee SH, Dominguez R, EMBO J. 2007 Oct 4;. PMID:17914456
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