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<Structure load='1ACJ' size='300' frame='true' align='right' caption= Insert caption here' /> 1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. | <Structure load='1ACJ' size='300' frame='true' align='right' caption= Insert caption here' /> 1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. | ||
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | ||
| - | It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 | + | It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 |
| - | <scene name='Sandbox_c2/Tacrine1/1'> | + | <scene name='Sandbox_c2/Tacrine1/1'>(W84 and F330)</scene>. |
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.' | Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.' | ||
Revision as of 13:08, 23 November 2010
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Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 .
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.'
