Sandbox c16
From Proteopedia
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Estructura acetilcolinesterasa | Estructura acetilcolinesterasa | ||
| - | <Structure load='1ACJ' size=' | + | <Structure load='1ACJ' size='300' frame='true' align='right' caption='acelit colinesterasa' /> |
1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. | 1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. | ||
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | ||
Revision as of 13:26, 23 November 2010
Estructura acetilcolinesterasa
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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 ( ).
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding [1]
- ↑ PMDI 8415649
