Sandbox c12

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<scene name='Sandbox_c12/Label/1'>Tacrines ring</scene> is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (<scene name='Sandbox_c12/Residuos_84_y_330/1'>W84 and F330</scene>)<ref>pmid 123</ref>
<scene name='Sandbox_c12/Label/1'>Tacrines ring</scene> is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (<scene name='Sandbox_c12/Residuos_84_y_330/1'>W84 and F330</scene>)<ref>pmid 123</ref>
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<references/>pmid 8415649.
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Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649.
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<references/>pmid 123
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Revision as of 13:28, 23 November 2010

TcAChE

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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 ()[1]

  1. ↑ Keighley MR, Asquith P, Edwards JA, Alexander-Williams J. The importance of an innervated and intact antrum and pylorus in preventing postoperative duodenogastric reflux and gastritis. Br J Surg. 1975 Oct;62(10):845-9. PMID:123
pmid 8415649.
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