This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox c5
From Proteopedia
| Line 11: | Line 11: | ||
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | ||
<references/> | <references/> | ||
| - | {{Seed}} | ||
| - | [[Image:2f76.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2f76", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
| - | {{STRUCTURE_2f76| PDB=2f76 | SCENE= }} | ||
| - | |||
| - | ===Solution structure of the M-PMV wild type matrix protein (p10)=== | ||
| - | |||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_18647839}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 18647839 is the PubMed ID number. | ||
| - | --> | ||
| - | {{ABSTRACT_PUBMED_18647839}} | ||
| - | |||
| - | ==About this Structure== | ||
| - | 2F76 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_retrovirus_1 Simian retrovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F76 OCA]. | ||
| - | |||
| - | ==Reference== | ||
| - | <ref group="xtra">PMID:18647839</ref><references group="xtra"/> | ||
| - | [[Category: Simian retrovirus 1]] | ||
| - | [[Category: Hrabal, R.]] | ||
| - | [[Category: Hunter, E.]] | ||
| - | [[Category: Lang, J.]] | ||
| - | [[Category: Lipov, J.]] | ||
| - | [[Category: Ruml, T.]] | ||
| - | [[Category: Rumlova, M.]] | ||
| - | [[Category: Srb, P.]] | ||
| - | [[Category: Veverka, V.]] | ||
| - | [[Category: Vlach, J.]] | ||
| - | [[Category: 4 alpha-helice]] | ||
| - | [[Category: Viral protein]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:02:05 2010'' | ||
Current revision
|
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 .
[1] Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
- ↑ PIMID 8415649
