Sandbox c5
From Proteopedia
(Difference between revisions)
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Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | ||
<references/> | <references/> | ||
| - | {{Seed}} | ||
| - | [[Image:2f76.png|left|200px]] | ||
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| - | The line below this paragraph, containing "STRUCTURE_2f76", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
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| - | {{STRUCTURE_2f76| PDB=2f76 | SCENE= }} | ||
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| - | ===Solution structure of the M-PMV wild type matrix protein (p10)=== | ||
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| - | The line below this paragraph, {{ABSTRACT_PUBMED_18647839}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 18647839 is the PubMed ID number. | ||
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| - | {{ABSTRACT_PUBMED_18647839}} | ||
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| - | ==About this Structure== | ||
| - | 2F76 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_retrovirus_1 Simian retrovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F76 OCA]. | ||
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| - | ==Reference== | ||
| - | <ref group="xtra">PMID:18647839</ref><references group="xtra"/> | ||
| - | [[Category: Simian retrovirus 1]] | ||
| - | [[Category: Hrabal, R.]] | ||
| - | [[Category: Hunter, E.]] | ||
| - | [[Category: Lang, J.]] | ||
| - | [[Category: Lipov, J.]] | ||
| - | [[Category: Ruml, T.]] | ||
| - | [[Category: Rumlova, M.]] | ||
| - | [[Category: Srb, P.]] | ||
| - | [[Category: Veverka, V.]] | ||
| - | [[Category: Vlach, J.]] | ||
| - | [[Category: 4 alpha-helice]] | ||
| - | [[Category: Viral protein]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:02:05 2010'' | ||
Current revision
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Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 .
[1] Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
- ↑ PIMID 8415649
