Sandbox c33
From Proteopedia
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Copy and paste the following line where you want the scene link to appear (scroll down if needed) and edit the TextToBeDisplayed: | Copy and paste the following line where you want the scene link to appear (scroll down if needed) and edit the TextToBeDisplayed: | ||
| - | <scene name='Sandbox_c33/Try_phenil/1'>W84 and F330</scene> | + | <scene name='Sandbox_c33/Try_phenil/1'>W84 and F330</scene> <scene name='Sandbox_c33/Trip_fenil_tacrine |
<scene name='Sandbox_c33/Try_phenil_label | <scene name='Sandbox_c33/Try_phenil_label | ||
<references/><PMID:8415649> | <references/><PMID:8415649> | ||
{{Seed}} | {{Seed}} | ||
[[Image:101m.png|left|200px]] | [[Image:101m.png|left|200px]] | ||
Revision as of 13:46, 23 November 2010
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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 ().
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
Copy and paste the following line where you want the scene link to appear (scroll down if needed) and edit the TextToBeDisplayed:
<PMID:8415649>
