2qt7

From Proteopedia

---

Revision as of 09:44, 23 January 2008

proteopedia linkproteopedia link

spinqualitylabelsall models 2qt7, resolution 1.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms

Overview

IA-2 is a protein-tyrosine phosphatase receptor located in secretory, granules of neuroendocrine cells. Initially, it attracted attention due to, its involvement in the autoimmune response associated to diabetes. Later, it was found that upon exocytosis, the cytoplasmic domain of IA-2 is, cleaved and relocated to the nucleus, where it enhances the transcription, of the insulin gene. A concerted functioning of the whole receptor is to, be expected. However, very little is known about the structure and, function of the transmembrane and extracellular domains of IA-2. To, address this issue, we solved the X-ray structure of the mature ectodomain, of IA-2 (meIA-2) to 1.30 A resolution. The fold of meIA-2 is related to, the SEA domains of mucins, suggesting its participation in adhesive, contacts to the extracellular matrix, and providing clues on how this kind, of molecules may associate and form homo- and heterodimers. Moreover, we, discovered that meIA-2 is self proteolyzed in vitro by reactive oxygen, species, suggesting the possibility of a new shedding mechanism that might, be significant in normal function or pathological processes. Knowledge of, meIA-2 structure should facilitate the search of its possible ligands and, molecular interactions.

About this Structure

2QT7 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Full crystallographic information is available from OCA.

Reference

Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2., Primo ME, Klinke S, Sica MP, Goldbaum FA, Jakoncic J, Poskus E, Ermacora MR, J Biol Chem. 2007 Nov 29;. PMID:18048354

Page seeded by OCA on Wed Jan 23 11:44:56 2008