2raj
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(New page: 200px<br /><applet load="2raj" size="350" color="white" frame="true" align="right" spinBox="true" caption="2raj, resolution 2.45Å" /> '''SO4 bound PX-BAR mem...)
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Revision as of 09:45, 23 January 2008
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SO4 bound PX-BAR membrane remodeling unit of Sorting Nexin 9
Overview
Sorting nexins (SNXs) form a family of proteins known to interact with, components in the endosomal system and to regulate various steps of, vesicle transport. Sorting nexin 9 (SNX9) is involved in the late stages, of clathrin-mediated endocytosis in non-neuronal cells, where together, with the GTPase dynamin, it participates in the formation and scission of, the vesicle neck. We report here crystal structures of the functional, membrane-remodeling unit of SNX9 and show that it efficiently tubulates, lipid membranes in vivo and in vitro. Elucidation of the protein, superdomain structure, together with mutational analysis and biochemical, and cell biological experiments, demonstrated how the SNX9 PX and BAR, domains work in concert in targeting and tubulation of, phosphoinositide-containing membranes. The study provides insights into, the SNX9-induced membrane modulation mechanism.
About this Structure
2RAJ is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
The PX-BAR membrane-remodeling unit of sorting nexin 9., Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR, Rak A, EMBO J. 2007 Nov 14;26(22):4788-800. Epub 2007 Oct 18. PMID:17948057
Page seeded by OCA on Wed Jan 23 11:45:25 2008
