3bci
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(New page: 200px<br /><applet load="3bci" size="350" color="white" frame="true" align="right" spinBox="true" caption="3bci, resolution 1.810Å" /> '''Crystal Structure o...)
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Revision as of 09:47, 23 January 2008
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Crystal Structure of Staphylococcus aureus DsbA
Overview
Bacterial Dsb proteins catalyse the in vivo formation of disulfide bonds, a critical step in the stability and activity of many proteins. Most, studies on Dsb proteins have focused on Gram-negative bacteria and thus, the process of oxidative folding in Gram-positive bacteria is poorly, understood. To help elucidate this process in Gram-positive bacteria, DsbA, from Staphylococcus aureus (SaDsbA) has been focused on. Here, the, expression, purification, crystallization and preliminary diffraction, analysis of SaDsbA are reported. SaDsbA crystals diffract to a resolution, limit of 2.1 A and belong to the hexagonal space group P6(5) or P6(1), with unit-cell parameters a = b = 72.1, c = 92.1 A and one molecule in the, asymmetric unit (64% solvent content).
About this Structure
3BCI is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Expression and crystallization of DsbA from Staphylococcus aureus., Heras B, Kurz M, Jarrott R, Byriel KA, Jones A, Thony-Meyer L, Martin JL, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt, 11):953-6. Epub 2007 Oct 24. PMID:18007049
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