Luciferase

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==See Also==
==See Also==
<applet load='2d1s' size='450' frame='true' align='right' scene='Luciferase/2d1s/1' caption='Luciferase ([[Luciola cruciata luciferase|2d1s]]) {{Link Toggle FancyCartoonHighQualityView}}.' />
<applet load='2d1s' size='450' frame='true' align='right' scene='Luciferase/2d1s/1' caption='Luciferase ([[Luciola cruciata luciferase|2d1s]]) {{Link Toggle FancyCartoonHighQualityView}}.' />
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*[[Luciola cruciata luciferase]] (Japanese firefly), complexed with Oxyluciferin & AMP ([[2d1r��]]) or with an high-energy analogue ([[2d1s]])
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*[[Luciola cruciata luciferase]] (Japanese firefly), complexed with Oxyluciferin & AMP ([[2d1r]]) or with an high-energy analogue ([[2d1s]])
*[[3ies]],[[3iep]] and [[3ier]] Firefly luciferase (FLuc) bound to its natural substrate ATP and the inhibitor PTC124<ref>PMID: 20194791</ref>
*[[3ies]],[[3iep]] and [[3ier]] Firefly luciferase (FLuc) bound to its natural substrate ATP and the inhibitor PTC124<ref>PMID: 20194791</ref>
*[[1ba3]] firefly luciferase enzyme from ''Photinus pyralis''
*[[1ba3]] firefly luciferase enzyme from ''Photinus pyralis''

Revision as of 09:05, 26 November 2010

Contents

Introduction

Several organisms are bioluminescent, meaning that they produce light. Luciferase is one of the enzymes that catalyzes light emitting reactions in organisms.

See Also

Luciferase (2d1s) <jmol> 

<jmolLink>
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Drag the structure with the mouse to rotate
  • Luciola cruciata luciferase (Japanese firefly), complexed with Oxyluciferin & AMP (2d1r) or with an high-energy analogue (2d1s)
  • 3ies,3iep and 3ier Firefly luciferase (FLuc) bound to its natural substrate ATP and the inhibitor PTC124[1]
  • 1ba3 firefly luciferase enzyme from Photinus pyralis
  • 2psd, 2pse, 2psf, 2psh, 2psj, and 2rh7 the luciferase from Renilla reniformis (RLuc)
  • 1bsl 1.95Å heterodimer of bacterial luciferase from Vibrio harveyi
  • 1brl 2.4Å heterodimer of bacterial luciferase from Vibrio harveyi
  • 1xkj homodimer of bacterial luciferase from Vibrio harveyi
  • 2d1q, 2d1r and 2d1s thermostable Japanese Firefly (Luciola cruciata) Luciferase complexed with High-energy intermediate analog
  • 2d1t thermostable Japanese Firefly Luciferase red-color emission S286N mutant
  • 1lci firefly luciferase enzyme from Photinus pyralis
  • Dinoflagellate luciferase
  • 1luc The 1.5Å resolution crystal structure of bacterial luciferase from Vibrio harveyi
  • 3fgc Bacterial luciferase from Vibrio harveyi[2]
  • 1vpr luciferase of Lingulodinium polyedrum, a marine bioluminescent dinoflagellate
  • Green Fluorescent Protein
  • For additional information, see: Colored & Bioluminescent Proteins

References

  1. ↑ Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. Epub 2010 Mar 1. PMID:20194791
  2. ↑ Campbell ZT, Weichsel A, Montfort WR, Baldwin TO. Crystal Structure of the Bacterial Luciferase:Flavin Complex Provides Insight into the Function of the subunit. Biochemistry. 2009 May 12. PMID:19435287 doi:http://dx.doi.org/10.1021/bi900003t


Additional Literature

  • Marques SM, Esteves da Silva JC. Firefly bioluminescence: a mechanistic approach of luciferase catalyzed reactions. IUBMB Life. 2009 Jan;61(1):6-17. PMID:18949818 doi:10.1002/iub.134
  • Inouye S. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Cell Mol Life Sci. 2010 Feb;67(3):387-404. Epub 2009 Oct 27. PMID:19859663 doi:10.1007/s00018-009-0170-8


External Resources

Retrieved from "http://52.214.119.220/wiki/index.php/Luciferase"
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