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Beta secretase
From Proteopedia
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'''β-Secretase''', also known as '''BACE''' ('''β'''-site of '''A'''myloid precursor protein '''C'''leaving '''E'''nzyme) and '''Memapsin 2''', is an aspartyl protease found in humans. β-Secretase plays an important role in the development of Alzheimer's disease. This has made β-secretase a therapeutic target for pharmacological intervention. | '''β-Secretase''', also known as '''BACE''' ('''β'''-site of '''A'''myloid precursor protein '''C'''leaving '''E'''nzyme) and '''Memapsin 2''', is an aspartyl protease found in humans. β-Secretase plays an important role in the development of Alzheimer's disease. This has made β-secretase a therapeutic target for pharmacological intervention. | ||
Revision as of 04:41, 30 November 2010
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β-Secretase, also known as BACE (β-site of Amyloid precursor protein Cleaving Enzyme) and Memapsin 2, is an aspartyl protease found in humans. β-Secretase plays an important role in the development of Alzheimer's disease. This has made β-secretase a therapeutic target for pharmacological intervention.
Contents |
Structure of Beta Secretase
Important Structures
Alzheimer's Disease
Inhibition of Beta Secretase
References
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Michal Harel, Alexander Berchansky, Daniel Santos, Jaime Prilusky, Joel L. Sussman, David Canner
