2jcw
From Proteopedia
(New page: 200px<br /> <applet load="2jcw" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jcw, resolution 1.7Å" /> '''REDUCED BRIDGE-BROKE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2JCW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with CU1 and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. This structure superseeds the now removed PDB entry 1JCW. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JCW OCA]]. | + | 2JCW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with CU1 and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. This structure superseeds the now removed PDB entry 1JCW. Active as [[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Structure known Active Sites: CU and ZN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JCW OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Superoxide dismutase]] | ||
[[Category: Balbirnie, M.M.]] | [[Category: Balbirnie, M.M.]] | ||
[[Category: Eisenberg, D.]] | [[Category: Eisenberg, D.]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:13:36 2007'' |
Revision as of 09:08, 30 October 2007
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REDUCED BRIDGE-BROKEN YEAST CU/ZN SUPEROXIDE DISMUTASE ROOM TEMPERATURE (298K) STRUCTURE
Overview
A reaction cycle is proposed for the mechanism of copper-zinc superoxide, dismutase (CuZnSOD) that involves inner sphere electron transfer from, superoxide to Cu(II) in one portion of the cycle and outer sphere electron, transfer from Cu(I) to superoxide in the other portion of the cycle. This, mechanism is based on three yeast CuZnSOD structures determined by X-ray, crystallography together with many other observations. The new structures, reported here are (1) wild type under 15 atm of oxygen pressure, (2) wild, type in the presence of azide, and (3) the His48Cys mutant. Final R-values, for the three structures are respectively 20.0%, 17.3%, and 20.9%., Comparison of these three new structures to the wild-type yeast Cu(I)ZnSOD, model, which has a broken imidazolate bridge, reveals the ... [(full description)]
About this Structure
2JCW is a [Single protein] structure of sequence from [Saccharomyces cerevisiae] with CU1 and ZN as [ligands]. This structure superseeds the now removed PDB entry 1JCW. Active as [Superoxide dismutase], with EC number [1.15.1.1]. Structure known Active Sites: CU and ZN. Full crystallographic information is available from [OCA].
Reference
A structure-based mechanism for copper-zinc superoxide dismutase., Hart PJ, Balbirnie MM, Ogihara NL, Nersissian AM, Weiss MS, Valentine JS, Eisenberg D, Biochemistry. 1999 Feb 16;38(7):2167-78. PMID:10026301
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