Tol

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==Regulation==
==Regulation==
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It has been shown that the regulation of Tol genes is linked to the cell envelope stability. <ref>PMCID: PMC1847374</ref> In studies with E. coli, the ''tol-pal'' genes have been induced by RcsC in response to cell envelope stress. <ref>PMID: 8821933</ref> RcsC is a transmembrane sensor kinase, and along with the cytoplasmic response regulator RcsB, makes up the RcsBC regulatory system. <ref>PMID: 16166540</ref> RcsBC is involved in the regulation of ''cps'' genes which code for the biosynthsis machinery of a major componant for the capsula, cholanic acid.
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It has been shown that the regulation of Tol genes is linked to the cell envelope stability. <ref>PMID: 17347522</ref> In studies with E. coli, the ''tol-pal'' genes have been induced by RcsC in response to cell envelope stress. <ref>PMID: 8821933</ref> RcsC is a transmembrane sensor kinase, and along with the cytoplasmic response regulator RcsB, makes up the RcsBC regulatory system. <ref>PMID: 16166540</ref> RcsBC is involved in the regulation of ''cps'' genes which code for the biosynthsis machinery of a major componant for the capsula, cholanic acid.
== References==
== References==
<references/>
<references/>

Revision as of 17:13, 3 December 2010

The Tol system, also known as Tol-Pal, is a multiprotein complex found in the cell envelope of many gram-negative bacteria. It contains 7 proteins (TolQ, TolR, TolA, TolB, Pal, YbgF, YbgC) organised into two operons.

Image:Tol Operon.jpg

Contents

Structure

Function

Regulation

It has been shown that the regulation of Tol genes is linked to the cell envelope stability. [1] In studies with E. coli, the tol-pal genes have been induced by RcsC in response to cell envelope stress. [2] RcsC is a transmembrane sensor kinase, and along with the cytoplasmic response regulator RcsB, makes up the RcsBC regulatory system. [3] RcsBC is involved in the regulation of cps genes which code for the biosynthsis machinery of a major componant for the capsula, cholanic acid.

References

  1. ↑ Cascales E, Buchanan SK, Duche D, Kleanthous C, Lloubes R, Postle K, Riley M, Slatin S, Cavard D. Colicin biology. Microbiol Mol Biol Rev. 2007 Mar;71(1):158-229. PMID:17347522 doi:10.1128/MMBR.00036-06
  2. ↑ Clavel T, Lazzaroni JC, Vianney A, Portalier R. Expression of the tolQRA genes of Escherichia coli K-12 is controlled by the RcsC sensor protein involved in capsule synthesis. Mol Microbiol. 1996 Jan;19(1):19-25. PMID:8821933
  3. ↑ Majdalani N, Heck M, Stout V, Gottesman S. Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli. J Bacteriol. 2005 Oct;187(19):6770-8. PMID:16166540 doi:10.1128/JB.187.19.6770-6778.2005

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