Tol
From Proteopedia
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The Tol system, also known as Tol-Pal, is a multiprotein complex found in the cell envelope of many gram-negative bacteria. It contains 7 proteins ([[TolQ]], [[TolR]], [[TolA]], [[TolB]], [[Pal]], [[YbgF]], [[YbgC]]) organised into two operons. | The Tol system, also known as Tol-Pal, is a multiprotein complex found in the cell envelope of many gram-negative bacteria. It contains 7 proteins ([[TolQ]], [[TolR]], [[TolA]], [[TolB]], [[Pal]], [[YbgF]], [[YbgC]]) organised into two operons. | ||
| - | [[Image: | + | [[Image:Tol Operon.jpg|420px| The Tol Operon]] |
==Structure== | ==Structure== | ||
Revision as of 17:21, 3 December 2010
The Tol system, also known as Tol-Pal, is a multiprotein complex found in the cell envelope of many gram-negative bacteria. It contains 7 proteins (TolQ, TolR, TolA, TolB, Pal, YbgF, YbgC) organised into two operons.
Contents |
Structure
Function
Regulation
It has been shown that the regulation of Tol genes is linked to the cell envelope stability. [1] In studies with E. coli, the tol-pal genes have been induced by RcsC in response to cell envelope stress. [2] RcsC is a transmembrane sensor kinase, and along with the cytoplasmic response regulator RcsB, makes up the RcsBC regulatory system. [3] RcsBC is involved in the regulation of cps genes which code for the biosynthsis machinery of a major componant for the capsula, cholanic acid.
References
- ↑ Cascales E, Buchanan SK, Duche D, Kleanthous C, Lloubes R, Postle K, Riley M, Slatin S, Cavard D. Colicin biology. Microbiol Mol Biol Rev. 2007 Mar;71(1):158-229. PMID:17347522 doi:10.1128/MMBR.00036-06
- ↑ Clavel T, Lazzaroni JC, Vianney A, Portalier R. Expression of the tolQRA genes of Escherichia coli K-12 is controlled by the RcsC sensor protein involved in capsule synthesis. Mol Microbiol. 1996 Jan;19(1):19-25. PMID:8821933
- ↑ Majdalani N, Heck M, Stout V, Gottesman S. Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli. J Bacteriol. 2005 Oct;187(19):6770-8. PMID:16166540 doi:10.1128/JB.187.19.6770-6778.2005
