User:Joanne Lau/sandbox 2
From Proteopedia
(Difference between revisions)
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| - | ==Unusual Features of the Hexameric ClpX== | + | ===Unusual Features of the Hexameric ClpX=== |
| - | + | Asymmetry and Falls into two classes of subunits | |
| - | == | + | ===ClpX as an ATPase=== |
| - | + | Angle changes and height changes, pulling a protein through to unfold it | |
| - | ==Interaction between ClpX and peptidase ClpP gives rise to Protein Degradation Machinery== | + | ===Central Pore of the Hexameric ClpX is Conserved=== |
| + | |||
| + | Central pore is critical, conserved. | ||
| + | |||
| + | ===How ClpX recognizes specific proteins=== | ||
| + | |||
| + | Itself can recognize proteins with certain motifs. Adaptors enhance reactivity, sspB, Rssb. | ||
| + | |||
| + | ===Interaction between ClpX and peptidase ClpP gives rise to Protein Degradation Machinery=== | ||
| + | |||
| + | Interaction between ClpX and ClpP donut in a row, which domain interacts. Critical to determine ClpX role as a chaperone or a protease. | ||
'''References''' | '''References''' | ||
Revision as of 03:50, 6 December 2010
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
Molecular Playground banner: ClpX protein ‘spring cleans’ the cell by sending specific proteins to the ‘dumpster’.
Intro
Contents |
Unusual Features of the Hexameric ClpX
Asymmetry and Falls into two classes of subunits
ClpX as an ATPase
Angle changes and height changes, pulling a protein through to unfold it
Central Pore of the Hexameric ClpX is Conserved
Central pore is critical, conserved.
How ClpX recognizes specific proteins
Itself can recognize proteins with certain motifs. Adaptors enhance reactivity, sspB, Rssb.
Interaction between ClpX and peptidase ClpP gives rise to Protein Degradation Machinery
Interaction between ClpX and ClpP donut in a row, which domain interacts. Critical to determine ClpX role as a chaperone or a protease.
References
