Cyclooxygenase
From Proteopedia
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{| class="wikitable" | {| class="wikitable" | ||
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| - | ! | + | ! Drug |
| - | ! | + | ! Coefficient of selectivity (IC50Cox-1/IC50Cox-2) |
| - | + | ||
|- | |- | ||
| row 1, cell 1 | | row 1, cell 1 | ||
| row 1, cell 2 | | row 1, cell 2 | ||
| - | | row 1, cell 3 | ||
|- | |- | ||
| row 2, cell 1 | | row 2, cell 1 | ||
| row 2, cell 2 | | row 2, cell 2 | ||
| - | | row 2, cell 3 | ||
|- | |- | ||
| row 3, cell 1 | | row 3, cell 1 | ||
| row 3, cell 2 | | row 3, cell 2 | ||
| - | | row | + | |- |
| + | | row 4, cell 1 | ||
| + | | row 4, cell 2 | ||
|} | |} | ||
Revision as of 10:29, 6 December 2010
Contents |
Crystal structure of COX-2
About this Structure
2I37 is a 3 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
NSAIDs
| Drug | Coefficient of selectivity (IC50Cox-1/IC50Cox-2) |
|---|---|
| row 1, cell 1 | row 1, cell 2 |
| row 2, cell 1 | row 2, cell 2 |
| row 3, cell 1 | row 3, cell 2 |
| row 4, cell 1 | row 4, cell 2 |
Reference
- Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
Page seeded by OCA on Tue Feb 17 02:59:53 2009
- Ghosh N, Chaki R, Mandal V, Mandal SC. COX-2 as a target for cancer chemotherapy. Pharmacol Rep. 2010 Mar-Apr;62(2):233-44. PMID:20508278
- Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145-82. PMID:10966456 doi:10.1146/annurev.biochem.69.1.145
- Rang HP, Dale MM, Ritter JM, Flower RJ. 2008. Pharmacology. Elsevier. 6th edition. 844 p.
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Cristina Murga, Michal Harel, David Canner, María Laura Saiz Álvarez, Alexander Berchansky
