Cyclooxygenase
From Proteopedia
(Difference between revisions)
| Line 23: | Line 23: | ||
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| Ketorolac | | Ketorolac | ||
| - | | 100-1000 | + | | <center> 100-1000 </center> |
|- | |- | ||
| Naproxen | | Naproxen | ||
Revision as of 10:39, 6 December 2010
Contents |
Crystal structure of COX-2
About this Structure
2I37 is a 3 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
NSAIDs
| Drug | Coefficient of selectivity (IC50Cox-1/IC50Cox-2) |
|---|---|
| Ketorolac | |
| Naproxen | 1-10 |
| Ibuprofen | 1-10 |
| Indometacin | 1-10 |
| Acetylsalicylic acid | 1 |
| Diclofenac | 1-0.1 |
| Valdecoxib | 0.01-0.001 |
| Etoricoxib | 0.01-0.001 |
Reference
- Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
Page seeded by OCA on Tue Feb 17 02:59:53 2009
- Ghosh N, Chaki R, Mandal V, Mandal SC. COX-2 as a target for cancer chemotherapy. Pharmacol Rep. 2010 Mar-Apr;62(2):233-44. PMID:20508278
- Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145-82. PMID:10966456 doi:10.1146/annurev.biochem.69.1.145
- Rang HP, Dale MM, Ritter JM, Flower RJ. 2008. Pharmacology. Elsevier. 6th edition. 844 p.
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