Cyclooxygenase
From Proteopedia
(Difference between revisions)
| Line 26: | Line 26: | ||
|- | |- | ||
| Naproxen | | Naproxen | ||
| - | | 1-10 | + | | <center> 1-10 </center> |
|- | |- | ||
| Ibuprofen | | Ibuprofen | ||
| - | | 1-10 | + | | <center> 1-10 </center> |
|- | |- | ||
| Indometacin | | Indometacin | ||
| - | | 1-10 | + | | <center> 1-10 </center> |
|- | |- | ||
| Acetylsalicylic acid | | Acetylsalicylic acid | ||
| - | | 1 | + | | <center> 1 </center> |
|- | |- | ||
| Diclofenac | | Diclofenac | ||
| - | | 1-0.1 | + | | <center> 1-0.1 </center> |
|- | |- | ||
| Valdecoxib | | Valdecoxib | ||
| - | | 0.01-0.001 | + | | <center> 0.01-0.001 </center> |
|- | |- | ||
| Etoricoxib | | Etoricoxib | ||
| - | | 0.01-0.001 | + | | <center> 0.01-0.001 </center> |
|} | |} | ||
Revision as of 10:41, 6 December 2010
Contents |
Crystal structure of COX-2
About this Structure
2I37 is a 3 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
NSAIDs
| Drug | Coefficient of selectivity (IC50Cox-1/IC50Cox-2) |
|---|---|
| Ketorolac | |
| Naproxen | |
| Ibuprofen | |
| Indometacin | |
| Acetylsalicylic acid | |
| Diclofenac | |
| Valdecoxib | |
| Etoricoxib | |
Reference
- Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
Page seeded by OCA on Tue Feb 17 02:59:53 2009
- Ghosh N, Chaki R, Mandal V, Mandal SC. COX-2 as a target for cancer chemotherapy. Pharmacol Rep. 2010 Mar-Apr;62(2):233-44. PMID:20508278
- Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145-82. PMID:10966456 doi:10.1146/annurev.biochem.69.1.145
- Rang HP, Dale MM, Ritter JM, Flower RJ. 2008. Pharmacology. Elsevier. 6th edition. 844 p.
Proteopedia Page Contributors and Editors (what is this?)
Cristina Murga, Michal Harel, David Canner, María Laura Saiz Álvarez, Alexander Berchansky
