Cyclooxygenase

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Revision as of 11:15, 6 December 2010

Template:STRUCTURE 6cox

Contents 1 Crystal structure of COX-2 2 About this Structure 3 NSAIDs 4 Reference

Crystal structure of COX-2

About this Structure

2I37 is a 3 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

NSAIDs

Table X: Selectivity of some NSAIDs

Drug	Coefficient of selectivity (IC50Cox-1/IC50Cox-2)
Ketorolac	100-1000
Naproxen	1-10
Ibuprofen	1-10
Indometacin	1-10
Acetylsalicylic acid	1
Diclofenac	1-0.1
Valdecoxib	0.01-0.001
Etoricoxib	0.01-0.001

Pharmacologic group	Drug	Salicylates	Acetylsalicylic acid
Propionic	Naproxen	Ibuprofen
	1	2
3	4

Reference

• Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607

Page seeded by OCA on Tue Feb 17 02:59:53 2009

• Ghosh N, Chaki R, Mandal V, Mandal SC. COX-2 as a target for cancer chemotherapy. Pharmacol Rep. 2010 Mar-Apr;62(2):233-44. PMID:20508278

• Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145-82. PMID:10966456 doi:10.1146/annurev.biochem.69.1.145

• Rang HP, Dale MM, Ritter JM, Flower RJ. 2008. Pharmacology. Elsevier. 6th edition. 844 p.