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Cyclooxygenase
From Proteopedia
(Difference between revisions)
| Line 62: | Line 62: | ||
|- | |- | ||
| Indolacetic || Indometacin | | Indolacetic || Indometacin | ||
| + | |- | ||
| Pirrolacetic || Ketorolac | | Pirrolacetic || Ketorolac | ||
| + | |- | ||
| Phenilacetic || Diclofenac | | Phenilacetic || Diclofenac | ||
| + | |- | ||
| Piranoidacetic || Etodolac | | Piranoidacetic || Etodolac | ||
| + | |- | ||
| Anthranilic || Mefenamic acid | | Anthranilic || Mefenamic acid | ||
| + | |- | ||
| Nicotinic || Clonixin | | Nicotinic || Clonixin | ||
| + | |- | ||
| Sulfonanilides || Nimesulide | | Sulfonanilides || Nimesulide | ||
| + | |+ Table X: Chemical variety of NSAIDs | ||
|} | |} | ||
Revision as of 11:23, 6 December 2010
Contents |
Crystal structure of COX-2
About this Structure
2I37 is a 3 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
NSAIDs
| Drug | Coefficient of selectivity (IC50Cox-1/IC50Cox-2) |
|---|---|
| Ketorolac | |
| Naproxen | |
| Ibuprofen | |
| Indometacin | |
| Acetylsalicylic acid | |
| Diclofenac | |
| Valdecoxib | |
| Etoricoxib | |
| Pharmacologic group | Drug |
|---|---|
| Salicylates | Acetylsalicylic acid |
| Propionic | Naproxen |
| Ibuprofen | |
| Para-aminophenols | Paracetamol |
| Indolacetic | Indometacin |
| Pirrolacetic | Ketorolac |
| Phenilacetic | Diclofenac |
| Piranoidacetic | Etodolac |
| Anthranilic | Mefenamic acid |
| Nicotinic | Clonixin |
| Sulfonanilides | Nimesulide |
Reference
- Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
Page seeded by OCA on Tue Feb 17 02:59:53 2009
- Ghosh N, Chaki R, Mandal V, Mandal SC. COX-2 as a target for cancer chemotherapy. Pharmacol Rep. 2010 Mar-Apr;62(2):233-44. PMID:20508278
- Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145-82. PMID:10966456 doi:10.1146/annurev.biochem.69.1.145
- Rang HP, Dale MM, Ritter JM, Flower RJ. 2008. Pharmacology. Elsevier. 6th edition. 844 p.
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