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Lapatinib
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| - | ===Pharmacokinetics=== | ||
| - | {| class="wikitable" border="1" width="40%" style="text-align:center" | ||
| - | |- | ||
| - | ! colspan="6" align="center"| VEGFR Inhibitor [[Pharmaceutical_Drugs#Pharmacokinetics_Translated|Pharmacokinetics]] <ref>D. Smith et al. Br J Clin Pharmacol. 2009 April; 67(4): 421–426.</ref><ref>R. Khosravan, et al. General Poster Session, Developmental Therapeutics: Cytotoxic Chemotherapy, J Clin Oncol 26: 2008 (May 20 suppl; abstr 2578)</ref><ref>PMID:16133532</ref><ref>PMID:20821331</ref><ref>PMID:20717111</ref> | ||
| - | |- | ||
| - | ! Parameter | ||
| - | ! [[Sunitinib]] (Sutent) | ||
| - | ! [[Sorafenib]] (Nexavar) | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr) | ||
| - | ! 8 | ||
| - | ! 8.3 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml) | ||
| - | ! 24.6 | ||
| - | ! 460 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%) | ||
| - | ! Variable | ||
| - | ! 29-49 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%) | ||
| - | ! 95 | ||
| - | ! 99 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr) | ||
| - | ! 83 | ||
| - | ! 29 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr) | ||
| - | ! 1921 | ||
| - | ! 11040 | ||
| - | |- | ||
| - | ! Dosage (mg) | ||
| - | ! 50 | ||
| - | ! 50 | ||
| - | |- | ||
| - | ! Metabolism | ||
| - | ! Hepatic (CYP3A4) | ||
| - | ! Hepatic (CYP3A4) | ||
| - | |} | ||
