Acetylcholine
From Proteopedia
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[[Image:acetylcholine.png| thumb | left|Acetylcholine]] | [[Image:acetylcholine.png| thumb | left|Acetylcholine]] | ||
| - | <applet load=' | + | <applet load='Ach1.pdb' size='400' frame='true' align='right' |
| - | scene='Acetylcholine/ | + | scene='Acetylcholine/Cv/1' /> |
| - | [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] ([http://www.expasy.org/enzyme/3.1.1.7 EC 3.1.1.7], ''e.g.'' from [http://en.wikipedia.org/wiki/Pacific_electric_ray ''Torpedo californica''], ''Tc''AChE) [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/ | + | [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] ([http://www.expasy.org/enzyme/3.1.1.7 EC 3.1.1.7], ''e.g.'' from [http://en.wikipedia.org/wiki/Pacific_electric_ray ''Torpedo californica''], ''Tc''AChE) [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Cv/2'>(ACh)</scene>, producing <scene name='2ace/Cv/3'>choline and an acetate</scene> group. ACh directly binds <scene name='2ace/Cv/4'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Cv/5'>catalytic triad (Ser200, His440, and Glu327)</scene> of (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Cv/6'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition. After this binding acetylcholinesterase <scene name='2ace/Cv/7'>hydrolysizes</scene> ACh. |
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Revision as of 12:22, 8 December 2010
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Acetylcholinesterase (EC 3.1.1.7, e.g. from Torpedo californica, TcAChE) hydrolysizes the neurotransmitter acetylcholine , producing group. ACh directly binds (via its nucleophilic Oγ atom) within the catalytic triad of (ACh/TcAChE structure 2ace). The residues are also important in the ligand recognition. After this binding acetylcholinesterase ACh.
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