Actin

From Proteopedia

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Revision as of 12:27, 9 December 2010

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Template:STRUCTURE 3hbt

Actin is a protein found in all eukaryotic cells. It is the monomer of two types of filaments: microfilaments which are part of the cytoskeleton and thin filaments which are part of muscles. Three isoforms of actin are identified: Alpha (Aa) (or G-actin) found in muscle tissue, beta (Ab) and gamma (Ag) actins are components of the cytoskeleton. F-actin is Aa bound to ATP. The images at the left and at the right correspond to one representative Actin, i.e. the crystal structure of rabbit Native G-actin (3hbt).

3D Structures of Actin

Alpha actin 1 (Aa)

2w49 – cAa +troponin C+ troponin T+ troponin I+ tropomyocin alpha-1 – chicken 1mdu – cAa+hGelsolin 3hbt, 2zwh, 1nwk, 1j6z – rAa – rabbit 2q1n, 2q31, 2a5x, 1rdw, 1rfq, 1lcu – rAa – dimer 2q36, 1qz5 – rAa+kabiramide C – dimer 2hmp – rAa – protease cleaved 2zwh, 2gwj, 2gwk – rAa-ATP 2vyp – rAa+myxobacterial rhizopodin 2v51, 2v52 – rAa+mMKL/Myocardin-like protein – mouse (m) 2vcp – rAa+ neural wiskott-aldrich syndrome protein (hWASP) – human (h) 2a3z, 2a40, 2a41 – rAa+cDNase I+domains of hWASP – cow (c) 2ff3 - rAa+ hGelsolin +domains of hWASP 2a42 – rAa+cDNase I 3daw – rAa+mTwinfilin-1 3buz – rAa+Iota toxin component IA 3b5u – rAa filament – fiber diffraction 1eqy, 3cjb, 1p8z – rAa+hGelsolin 1rgi - rAa+hoGelsolin – horse (ho) 1t44 - rAa+hGelsolin:mThymosin B4 1esv - rAa+hGelsolin+ latrunculin A 3cjc - rAa+hGelsolin+cDNase I 2d1k - rAa+hWH2 domain of MIN+cDNase I 2pbd – rAa+hProfilin-1 2pav - rAa+hProfilin-1+hVASP 2q97 – rAa+toxofilin – Toxoplasma gondii 2q0r – rAa+pectenotoxin-2 2q0u - rAa+pectenotoxin-2+latrunculin B 1ijj - rAa+latrunculin A 2fxu – rAa+bistramide A 1wua – rAa+alpyronine A 2asm, 2asp – rAa+reidispongiolide 2aso – rAa+sphinxolide B 1yxq – rAa+swinholide A 1y64 – rAa+yBNI1 domain FH2 - yeast 1sqk – rAa+DmCiboulot - Drosophila melanogaster (Dm) 2ff6 - rAa+DmCiboulot+hGelsolin 1s22 – rAa+ulapualide A 1qz6 – rAa+jaspisamide A 1lot, 1kxp, 1ma9 – rAa+hVitamin D binding protein

Beta actin (Ab)

3lue – hAb+hAlpha-actinin 3byh – hAb+hFimbrin ABD2 – Cryo EM 2oan – cAb

Gamma 1 actin (Ag)

1atn – rAg+cDNase I 3chw – Major DdAg+hProfilin+poly-Pro repeat – Dictyostelium discoideum 3ci5, 3cip, 1nmd - Major DdAg+hGelsolin 1c0g, 1dej – DdAg:tetrahymenatA+hGelsolin 1nm1 - DdAg+hGelsolin+Mg-ATP 1nlv, 1c0f – DdAg+hGelsolin 1d4x – Ag 1/3+hGelsolin – C. elegans 1h1v – hAg+rGelsolin 1hlu, 2btf – cA+cProfilin 1o1g, 1o1a-f, 1o18, 1o19, 1mvw, 1m8q –cAg+cMyosin II - tomography 3eks – DmAg 5c (mutant) 3eku – DmAg 5c (mutant)+cytochalasin D 3el2, 2hf4 - DmAg 5c (mutant)+Ca-ATP 2hf3 - DmAg 5c (mutant)+Ca-ADP 3b63 – actin filament – Limulus polyphemus 1yvn – yA (mutant)+hGelsolin 1yag - yA+hGelsolin