NSAID Pharmacokinetics

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Line 26:		Line 26:
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
	! 2.94		! 2.94
-	! Celecoxib (Celebrex)	+	! 2.8
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
Line 43:		Line 43:
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
	! 340		! 340
-	! Celecoxib (Celebrex)	+	! 614)
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
Line 77:		Line 77:
	! 99		! 99
	! 98		! 98
-	! Celecoxib (Celebrex)	+	! 97
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
Line 94:		Line 94:
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
	! Valdecoxib (Bextra)		! Valdecoxib (Bextra)
-	! Celecoxib (Celebrex)	+	! 11.2
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
Line 111:		Line 111:
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
	! 7548		! 7548
-	! Celecoxib (Celebrex)	+	! 6930
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
Line 162:		Line 162:
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
	! Valdecoxib (Bextra)		! Valdecoxib (Bextra)
-	! Celecoxib (Celebrex)	+	! 27.7
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
Line 179:		Line 179:
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
	! 20		! 20
-	! Celecoxib (Celebrex)	+	! 200
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
Line 196:		Line 196:
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
	! Hepatic (CYP3A4 & CYP2C9)		! Hepatic (CYP3A4 & CYP2C9)
-	! Celecoxib (Celebrex)	+	! Hepatic (CYP2C9)
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)

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Revision as of 19:27, 9 December 2010

Cyclooxygenase Inhibitor Pharmacokinetics
Parameter	Ibuprofen (Advil)	Naproxen (Aleve)	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Tmax (hr)	1.3	.92	2.29	Acetylsalicylic Acid (Aspirin)	2.94	2.8	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Cmax (ng/ml)	16200	47100	19670	Acetylsalicylic Acid (Aspirin)	340	614)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Bioavailability (%)	49-73	95	96	Acetylsalicylic Acid (Aspirin)	83	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Protein Binding (%)	99	99	99	99	98	97	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
T1/2 (hr)	2.4	18.7	4.77	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	11.2	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
AUC (ng/ml/hr)	67400	777400	124320	Acetylsalicylic Acid (Aspirin)	7548	6930	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
IC50 COX-1 (nM)	18	11	Flurbiprofen (Ansaid)	342	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
IC50 COX-2 (nM)	1030	1015	Flurbiprofen (Ansaid)	>5000	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Clearance (L/h)	3.4	Naproxen (Aleve)	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	27.7	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Dosage (mg)	400	200	150	Acetylsalicylic Acid (Aspirin)	20	200	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Metabolism	Hepatic (CYP2C9)	Naproxen	Hepatic (CYP2C9)	Acetylsalicylic Acid (Aspirin)	Hepatic (CYP3A4 & CYP2C9)	Hepatic (CYP2C9)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)

For references, see: References