NSAID Pharmacokinetics

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Line 23:		Line 23:
	! 1.3		! 1.3
	! .92		! .92
-	! 2.29	+	! 2.3
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
-	! 2.94	+	! 2.9
	! 2.8		! 2.8
-	! Sulindac (Clinoril)	+	! 3.4
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
	! Piroxicam (Feldene)		! Piroxicam (Feldene)
Line 43:		Line 43:
	! Acetylsalicylic Acid (Aspirin)		! Acetylsalicylic Acid (Aspirin)
	! 340		! 340
-	! 614)	+	! 705
	! Sulindac (Clinoril)		! Sulindac (Clinoril)
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
Line 95:		Line 95:
	! Valdecoxib (Bextra)		! Valdecoxib (Bextra)
	! 11.2		! 11.2
-	! Sulindac (Clinoril)	+	! 7.8
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
	! Piroxicam (Feldene)		! Piroxicam (Feldene)
Line 163:		Line 163:
	! Valdecoxib (Bextra)		! Valdecoxib (Bextra)
	! 27.7		! 27.7
-	! Sulindac (Clinoril)	+	! 4.1
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
	! Piroxicam (Feldene)		! Piroxicam (Feldene)
Line 180:		Line 180:
	! 20		! 20
	! 200		! 200
-	! Sulindac (Clinoril)	+	! 200
	! Oxaprozin (Daypro)		! Oxaprozin (Daypro)
	! Piroxicam (Feldene)		! Piroxicam (Feldene)

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Revision as of 19:41, 9 December 2010

Cyclooxygenase Inhibitor Pharmacokinetics
Parameter	Ibuprofen (Advil)	Naproxen (Aleve)	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Tmax (hr)	1.3	.92	2.3	Acetylsalicylic Acid (Aspirin)	2.9	2.8	3.4	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Cmax (ng/ml)	16200	47100	19670	Acetylsalicylic Acid (Aspirin)	340	705	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Bioavailability (%)	49-73	95	96	99	83	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Protein Binding (%)	99	99	99	99	98	97	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
T1/2 (hr)	2.4	18.7	4.77	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	11.2	7.8	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
AUC (ng/ml/hr)	67400	777400	124320	Acetylsalicylic Acid (Aspirin)	7548	6930	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
IC50 COX-1 (nM)	18	11	Flurbiprofen (Ansaid)	342	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
IC50 COX-2 (nM)	1030	1015	Flurbiprofen (Ansaid)	>5000	Valdecoxib (Bextra)	Celecoxib (Celebrex)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Clearance (L/h)	3.4	Naproxen (Aleve)	Flurbiprofen (Ansaid)	Acetylsalicylic Acid (Aspirin)	Valdecoxib (Bextra)	27.7	4.1	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Dosage (mg)	400	200	150	Acetylsalicylic Acid (Aspirin)	20	200	200	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)
Metabolism	Hepatic (CYP2C9)	Hepatic (CYP2C9)	Hepatic (CYP2C9)	Acetylsalicylic Acid (Aspirin)	Hepatic (CYP3A4 & CYP2C9)	Hepatic (CYP2C9)	Sulindac (Clinoril)	Oxaprozin (Daypro)	Piroxicam (Feldene)	Nabumetone (Relafen)	Acetaminophen (Paracetamol)	Mefanamic Acid (Ponstel)	Ketorolac (Toradol)	Rofecoxib (Vioxx)	Diclofenac (Voltaren)

For references, see: References