Retroviral Integrase Inhibitor Pharmacokinetics
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Revision as of 09:21, 10 December 2010
| Retroviral Integrase Inhibitor Pharmacokinetics | |||
|---|---|---|---|
| Parameter | Raltegravir | Elvitegravir | MK-2048 |
| Tmax (hr) | 1.8 | 2-4 | N/A |
| Cmax (ng/ml) | 4253 | 2070 | N/A |
| Bioavailability (%) | 32 | ~30 | N/A |
| Protein Binding (%) | 83 | N/A | N/A |
| T1/2 (hr) | 10.8 | 7.6 | N/A |
| AUC (ng/ml/hr) | 10168 | 21200 | N/A |
| Dosage (mg) | 400 | 150 | N/A |
| Metabolism | Hepatic - (UGT1A1) | Hepatic - (CYP3A4) | N/A |
For Pharmacokinetic Data References, See: References
