M2 Proton Channel Inhibitor Pharmacokinetics
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Revision as of 09:25, 10 December 2010
| M2 Proton Channel Inhibitor Pharmacokinetics | ||||||
|---|---|---|---|---|---|---|
| Parameter | Rimantadine | Amantadine | ||||
| Tmax (hr) | 4.3 | 2.5 | ||||
| Cmax (ng/ml) | 310 | 402 | ||||
| Bioavailability (%) | >90 | >90 | ||||
| Protein Binding (%) | 40 | 67 | ||||
| T1/2 (hr) | 27.7 | ~15 | ||||
| AUC (ng/ml/hr) | 11917 | 5420 | ||||
| Dosage (mg) | 100 | 100 | ||||
| Metabolism | Negligible | Negligible | ||||
For Pharmacokinetic Data References, See: References
