Neuraminidase Inhibitor Pharmacokinetics
From Proteopedia
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! colspan="12" align="center"| Neuraminidase Inhibitor [[Pharmacokinetics]] | ! colspan="12" align="center"| Neuraminidase Inhibitor [[Pharmacokinetics]] | ||
Current revision
| Neuraminidase Inhibitor Pharmacokinetics | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Zanamivir | Oseltamivir | |||||||||
| Tmax (hr) | 1.25 | 1.5 | |||||||||
| Cmax (ng/ml) | 31.6 | 57 | |||||||||
| Bioavailability (%) | 2 | 75 | |||||||||
| Protein Binding (%) | 10 | 42 | |||||||||
| T1/2 (hr) | 3 | 3.2 | |||||||||
| AUC (ng/ml/hr) | 185 | 204 | |||||||||
| Clearance (L/h) | 54.1 | 18.8 | |||||||||
| Dosage (mg) | 10 | 300 | |||||||||
| Metabolism | None | Hepatic | |||||||||
For References to Pharmacokinetic data, see: References
