2r7g
From Proteopedia
(New page: 200px<br /> <applet load="2r7g" size="450" color="white" frame="true" align="right" spinBox="true" caption="2r7g, resolution 1.671Å" /> '''Structure of the r...) |
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| - | [[Image:2r7g.gif|left|200px]]<br /> | + | [[Image:2r7g.gif|left|200px]]<br /><applet load="2r7g" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2r7g, resolution 1.671Å" /> | caption="2r7g, resolution 1.671Å" /> | ||
'''Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain'''<br /> | '''Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain'''<br /> | ||
| - | == | + | ==Overview== |
| - | + | The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma, protein (pRb) tumor suppressor. In this study we determined the crystal, structure of the pRb pocket domain in complex with conserved region 1, (CR1) of Ad5-E1A. The structure and accompanying biochemical studies, reveal that E1A-CR1 binds at the interface of the A and B cyclin folds of, the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation, domain use similar conserved nonpolar residues to engage overlapping sites, on pRb, implicating a novel molecular mechanism for pRb inactivation by a, viral oncoprotein. | |
==About this Structure== | ==About this Structure== | ||
| - | 2R7G is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/ | + | 2R7G is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_4 Human adenovirus type 4] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7G OCA]. |
| + | |||
| + | ==Reference== | ||
| + | Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17974914 17974914] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Human adenovirus | + | [[Category: Human adenovirus type 4]] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Liu, X.]] | [[Category: Liu, X.]] | ||
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[[Category: transcription repressor]] | [[Category: transcription repressor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:06:59 2008'' |
Revision as of 10:06, 23 January 2008
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Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
Overview
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma, protein (pRb) tumor suppressor. In this study we determined the crystal, structure of the pRb pocket domain in complex with conserved region 1, (CR1) of Ad5-E1A. The structure and accompanying biochemical studies, reveal that E1A-CR1 binds at the interface of the A and B cyclin folds of, the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation, domain use similar conserved nonpolar residues to engage overlapping sites, on pRb, implicating a novel molecular mechanism for pRb inactivation by a, viral oncoprotein.
About this Structure
2R7G is a Protein complex structure of sequences from Homo sapiens and Human adenovirus type 4 with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914
Page seeded by OCA on Wed Jan 23 12:06:59 2008
