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Cytochrome P450

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(New page: Crystal Structure of Cytochrome P450 2f9q {{STRUCTURE_2f9q| PDB=2f9q | SIZE=300| SCENE= |right|CAPTION=Cytochrome P450 2f9q }})
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[[Image:2f9q.png|left|200px|thumb|Crystal Structure of Cytochrome P450 [[2f9q]]]]
[[Image:2f9q.png|left|200px|thumb|Crystal Structure of Cytochrome P450 [[2f9q]]]]
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{{STRUCTURE_2f9q| PDB=2f9q | SIZE=300| SCENE= |right|CAPTION=Cytochrome P450 [[2f9q]] }}
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{{STRUCTURE_2f9q| PDB=2f9q | SIZE=300| SCENE=Cytochrome_P450/Cv/1 |right|CAPTION=Cytochrome P450 [[2f9q]] }}
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Cytochrome P450 (CYP) catalyzes the oxidation of organic substances like lipids. The CYP contains a heme cofactor. The protein is numbered by its gene. CYP-cam catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase CYP. The images at the left and at the right correspond to one representative CYP, ''i.e.'' the crystal structure of human CYP2 ([[2f9q]]).
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{{TOC limit|limit=2}}
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== 3D Structures of Cytochrome P450 ==
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=== CYP/P450 reductase ===
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[[3kx3]], [[3kx4]], [[3kx5]], [[3hf2]], [[3dgi]], [[3cbd]], [[2nnb]], [[1zo4]], [[2yqo]], [[2yqp]], [[1smi]], [[1p0v]], [[1p0w]], [[1p0x]], [[1jme]] – BmCYP102A1/P450 reductase (mutant) – ''Bacilus megaterium''
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[[1zo9]] - BmCYP102A1/P450 reductase+N-palmitoylmethionine
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[[1zoa]], [[1jpz]] - BmCYP102A1/P450 reductase (mutant)+N-palmitoylglycine
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[[1smj]] - BmCYP102A1/P450 reductase (mutant)+N-palmitoleate
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=== human CYP1 family ===
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2hi4 – hCYP1A2+naphthoflavone - human
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=== human CYP2 family ===
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3gph, 3koh, 3lc4 – hCYP2E1 fragment +imidazole derivative
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3e6i – hCYP2E1 fragment+indazole
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3ebs – hCYP2A6 (mutant)+phenacetin
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2fdu, 2fdv, 2fdw, 2fdy - hCYP2A6+pyridine derivative
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3e4e – hCYP2E1 fragment+methylpyrazole
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3czh, 3dl9, 3c6g – hCYP2R1+vitamin D
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2nnh – hCYP2C8+retinoic acid
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2nni - hCYP2C8+montelukast
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2nnj - hCYP2C8+felodipine
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1pq2 - hCYP2C8
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1og2, 1og5 – hCYP2C9 (mutant)
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1r9o – hCYP2C9 (mutant)+flurbiprofen
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2pg5, 2pg6, 2pg7 – hCYP2A6 (mutant)
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2p85 – hCYP2A13 (mutant)+indole
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3ibd – hCYP2B6 (mutant)+4-(4-chlorophenyl)imidazole
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2f9q – hCYP2D6
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2z10 – hCYP2A6+coumarin
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1z11 - hCYP2A6+methoxalen
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=== human CYP3 family ===
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2v0m – hCYP3A4+ketoconazole
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2j0d - hCYP3A4+erythromycin
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1tqn, 1w0e, 1w0f, 1w0g – hCYP3A4
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=== human CYP7 family ===
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3dax – hCYP7A1
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=== human CYP19 family ===
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3eqm - hCYP19A1+androstenedione
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=== human CYP46 family ===
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2q9f – hCYP46A1+cholesterol
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2q9d - hCYP46A1
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2vn0 – hCYP105A1+troglitazone
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2zby - hCYP105A1 (mutant)
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=== CYP from Mycobacterium tuberculosis ===
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2vku, 1h5z – MtCYP51 - Mycobacterium tuberculosis
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2ci0, 2cib, 1u13 - MtCYP51 (mutant)
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1x8v - MtCYP51 (mutant)+estriol
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1ea1 - MtCYP51 (mutant)+ fluconazole
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1e9x - MtCYP51 (mutant)+ phenylimidazole
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3cxv, 3cxx, 3cxy, 3cxz, 3cy0, 3cy1 - MtCYP121 (mutant)
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3g5f, 3g5h, 2ij5, 1n40 – MtCYP121
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2ij7 - MtCYP121+fluconazole
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1n4g - MtCYP121+iodopyrazole
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3ivi, 3iw0 – MtCYP125
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3iw1 - MtCYP125+androstenedione
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3iw2 - MtCYP125+econazole
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2uvn - MtCYP130+econazole
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2wgy – MtCYP130 (mutant)
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2w09, 2w0b, 2w0a - MtCYP130 (mutant)+pyridine inhibitor
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2uuq – MtCYP130
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=== CYP-cam ===
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2qbl, 2qbm, 2qbn, 2gqx, 2gr6, 2frz, 2h7s, 6cp4, 2cp4, 3cp4, 4cp4 – PpCYP-cam (mutant) – Pseudomona putida
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1dz4, 1dz8, 1dz6, 1dz9, 5cp4, 1phc, 2cpp - PpCYP-cam
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2qbo - PpCYP-cam (mutant)+cyanide
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1qmq - PpCYP-cam (mutant)+Ru substrate
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2h7q - PpCYP-cam+imidazole
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1cp4 - PpCYP-cam+benzene
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1akd - PpCYP-cam+1S-camphor
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2fe6, 2fer, 2feu - PpCYP-cam+Mn protoporphyrin IX
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1uyu - PpCYP-cam + Xe
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1076 - PpCYP-cam +cyanide
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4cpp - PpCYP-cam+adamantine
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5cpp - PpCYP-cam+adamantanone
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6cpp - PpCYP-cam+camphene
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7cpp - PpCYP-cam+norcamphor
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8cpp- PpCYP-cam+thiocamphor
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3cpp - PpCYP-cam+CO
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1pha, 1phb, 1phd, 1phe, 1phf, 1phg - PpCYP-cam+imidazole derivative
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1gek, 1gem - PpCYP-cam +N-butyl-isocyanide
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1lwl - PpCYP-cam +fluorescent probe
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2h7r - PpCYP-cam (mutant)+imidazole
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1k2o - PpCYP-cam (mutant)+pyridine derivative
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1gjm - PpCYP-cam (mutant)+sulphydryl reagent
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2a1m, 2a1n, 2a10 - PpCYP-cam (mutant)+ferrous dioxygen
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1t85, 1t86, 1t87, 1t88 - PpCYP-cam (mutant)+ferrous CO
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=== P450nor ===
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1cl6, 1rom – FoP450nor - Fusarium oxysporum
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2rom - FoP450nor+CO
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1cmj, 1cmn - FoP450nor (mutant)
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1xqd – FoP450nor+pyridinealdehyde adenine
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1jfb, 1jfc, 1ged - FoP450nor
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1gej, 1gei - FoP450nor+N-butyl-isocyanide
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1ulw - FoP450nor (mutant)
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=== rabbit CYP ===
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2bdm – rCYP2B4 – rabbit
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1po5 - rCYP2B4 (mutant)
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1suo - rCYP2B4 (mutant)+imidazole
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1dt6 - rCYP2C5 (mutant)
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1nr6 – rCYP2C5+diclofenac
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1n6b - rCYP2C5+sulfaphenazole
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=== Other CYPs ===
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1ued – AoCYP oxyC – Amycolatopsis orientalis
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1lfk, 1lg9, 1lgf - AoCYP oxyB
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1q5d – ScCYPEPOK+epothilone – Sorangium cellulosum
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1q5e - ScCYPEPOK
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1io8 – SsCYP119 (mutant) – Sulfolobus solfataricus
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1io9, 1io7, 1f4u - SsCYP119
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1f4t - SsCYP119+ phenylimidazole
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1cpt – CYP108 – Pseudomonas sp.
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2uwh - BmCYP102+palmitic acid
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3ekb, 3ekd, 3ekf, 2ij3, 2ij4 - BmCYP102 heme domain (mutant)
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2ij2, 2hpd - BmCYP102 heme domain
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3ben - BmCYP102 + imidazole derivative
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2j1m, 2j4s - BmCYP102+DMSO
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1bvy, 1bu7– BmCYP102A1 FMN domain
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1fag – BmCYP102A1+ palmitic acid
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1fah – BmCYP102A1 (mutant)
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2bmh - BmCYP102A1
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3aba – SaCYP105P1+filipin I – Streptomyces avermitilis
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3abb – SaCYP105D6
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3e5j, 3e5l - SaCYP105P1 (mutant)
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3e5k - SaCYP105P1 (mutant)+4-phenylimidazole
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2whw, 2wi9, 2vz7 – SvCYP107L1 (mutant) – Streptomyces venezuelae
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2vzm – SvCYP107L1 (mutant)+narbomycin
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2c7x - SvCYP107L1+narbomycin
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2cd8, 2ca0, 2c6h – SvCYP107L1+YC-17
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2bvj - SvCYP107L1
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2zqj – BsCYP152A1 – Bacillus subtilis
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2zqx - BsCYP152A1+heptanoic acid
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1izo – BsCYP BS beta+ palmitoleic acid
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1jin, 1jip - SeCYP107A1+ ketoconazole - Saccharopolyspora erythraea
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1jio, 1oxa - SeCYP107A1+6DEB
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1eup – SeCYP107A1+androstendione
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1egy - SeCYP107A1+aminophenanthrene
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2jjn, 2jjo - SeCYP113A1 (mutant)
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2jjp - SeCYP113A1 (mutant)+ketoconazole
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2vrv - SeCYP113A1 (mutant)+clotrimazole
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3a1l – SsCYP245A1+dichlorochrompyrrolic acid – Streptomyces sp.
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2z3t - SsCYP245A1
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2z3u - SsCYP245A1+chromopyrrolic acid
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3g5n, 3g93 – rCYP2B4 (mutant)+1-biphenyl-4-methyl-1H-imidazole – rabbit
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2q6n – rCYP2B4 (mutant)+chlorophenyl-imidazole
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3cv8 – SgCYP105A1 (mutant) – Streptomyces griseolus
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3cv9, 2zbz - SgCYP105A1 (mutant)+vitamin D3
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2zbx - SgCYP105A1+imidazole
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3dam, 3dan, 3dbm– CYP74A2 – Parthenium argentatum
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2rch, 3dsi – AtCYP74A+13(S)-HOD – Arabidopsis thaliana
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3dsj - AtCYP74A (mutant)+13(S)-HOD
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2rcl - AtCYP74A+vernolic acid
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3dsk - AtCYP74A (mutant)+ vernolic acid
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2rcm, 3cli - AtCYP74A
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2rfb – PtCYP – Picrophilus torridus
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2rfc – PtCYP+phenylimidazole
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2nz5, 2nza, 2dkk – ScCYP158A1 – Streptomyces coelicolor
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1gwi - ScCYP154C1
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1wiy – TtCYP – Thermus thermophilus
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1n97 – TtCYP175A1

Revision as of 10:46, 13 December 2010

Image:2f9q.png
Crystal Structure of Cytochrome P450 2f9q

Template:STRUCTURE 2f9q

Cytochrome P450 (CYP) catalyzes the oxidation of organic substances like lipids. The CYP contains a heme cofactor. The protein is numbered by its gene. CYP-cam catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase CYP. The images at the left and at the right correspond to one representative CYP, i.e. the crystal structure of human CYP2 (2f9q).

Contents

3D Structures of Cytochrome P450

CYP/P450 reductase

3kx3, 3kx4, 3kx5, 3hf2, 3dgi, 3cbd, 2nnb, 1zo4, 2yqo, 2yqp, 1smi, 1p0v, 1p0w, 1p0x, 1jme – BmCYP102A1/P450 reductase (mutant) – Bacilus megaterium 1zo9 - BmCYP102A1/P450 reductase+N-palmitoylmethionine 1zoa, 1jpz - BmCYP102A1/P450 reductase (mutant)+N-palmitoylglycine 1smj - BmCYP102A1/P450 reductase (mutant)+N-palmitoleate


human CYP1 family

2hi4 – hCYP1A2+naphthoflavone - human


human CYP2 family

3gph, 3koh, 3lc4 – hCYP2E1 fragment +imidazole derivative 3e6i – hCYP2E1 fragment+indazole 3ebs – hCYP2A6 (mutant)+phenacetin 2fdu, 2fdv, 2fdw, 2fdy - hCYP2A6+pyridine derivative 3e4e – hCYP2E1 fragment+methylpyrazole 3czh, 3dl9, 3c6g – hCYP2R1+vitamin D 2nnh – hCYP2C8+retinoic acid 2nni - hCYP2C8+montelukast 2nnj - hCYP2C8+felodipine 1pq2 - hCYP2C8 1og2, 1og5 – hCYP2C9 (mutant) 1r9o – hCYP2C9 (mutant)+flurbiprofen 2pg5, 2pg6, 2pg7 – hCYP2A6 (mutant) 2p85 – hCYP2A13 (mutant)+indole 3ibd – hCYP2B6 (mutant)+4-(4-chlorophenyl)imidazole 2f9q – hCYP2D6 2z10 – hCYP2A6+coumarin 1z11 - hCYP2A6+methoxalen


human CYP3 family

2v0m – hCYP3A4+ketoconazole 2j0d - hCYP3A4+erythromycin 1tqn, 1w0e, 1w0f, 1w0g – hCYP3A4


human CYP7 family

3dax – hCYP7A1


human CYP19 family

3eqm - hCYP19A1+androstenedione


human CYP46 family

2q9f – hCYP46A1+cholesterol 2q9d - hCYP46A1 2vn0 – hCYP105A1+troglitazone 2zby - hCYP105A1 (mutant)


CYP from Mycobacterium tuberculosis

2vku, 1h5z – MtCYP51 - Mycobacterium tuberculosis 2ci0, 2cib, 1u13 - MtCYP51 (mutant) 1x8v - MtCYP51 (mutant)+estriol 1ea1 - MtCYP51 (mutant)+ fluconazole 1e9x - MtCYP51 (mutant)+ phenylimidazole 3cxv, 3cxx, 3cxy, 3cxz, 3cy0, 3cy1 - MtCYP121 (mutant) 3g5f, 3g5h, 2ij5, 1n40 – MtCYP121 2ij7 - MtCYP121+fluconazole 1n4g - MtCYP121+iodopyrazole 3ivi, 3iw0 – MtCYP125 3iw1 - MtCYP125+androstenedione 3iw2 - MtCYP125+econazole 2uvn - MtCYP130+econazole 2wgy – MtCYP130 (mutant) 2w09, 2w0b, 2w0a - MtCYP130 (mutant)+pyridine inhibitor 2uuq – MtCYP130


CYP-cam

2qbl, 2qbm, 2qbn, 2gqx, 2gr6, 2frz, 2h7s, 6cp4, 2cp4, 3cp4, 4cp4 – PpCYP-cam (mutant) – Pseudomona putida 1dz4, 1dz8, 1dz6, 1dz9, 5cp4, 1phc, 2cpp - PpCYP-cam 2qbo - PpCYP-cam (mutant)+cyanide 1qmq - PpCYP-cam (mutant)+Ru substrate 2h7q - PpCYP-cam+imidazole 1cp4 - PpCYP-cam+benzene 1akd - PpCYP-cam+1S-camphor 2fe6, 2fer, 2feu - PpCYP-cam+Mn protoporphyrin IX 1uyu - PpCYP-cam + Xe 1076 - PpCYP-cam +cyanide 4cpp - PpCYP-cam+adamantine 5cpp - PpCYP-cam+adamantanone 6cpp - PpCYP-cam+camphene 7cpp - PpCYP-cam+norcamphor 8cpp- PpCYP-cam+thiocamphor 3cpp - PpCYP-cam+CO 1pha, 1phb, 1phd, 1phe, 1phf, 1phg - PpCYP-cam+imidazole derivative 1gek, 1gem - PpCYP-cam +N-butyl-isocyanide 1lwl - PpCYP-cam +fluorescent probe 2h7r - PpCYP-cam (mutant)+imidazole 1k2o - PpCYP-cam (mutant)+pyridine derivative 1gjm - PpCYP-cam (mutant)+sulphydryl reagent 2a1m, 2a1n, 2a10 - PpCYP-cam (mutant)+ferrous dioxygen 1t85, 1t86, 1t87, 1t88 - PpCYP-cam (mutant)+ferrous CO


P450nor

1cl6, 1rom – FoP450nor - Fusarium oxysporum 2rom - FoP450nor+CO 1cmj, 1cmn - FoP450nor (mutant) 1xqd – FoP450nor+pyridinealdehyde adenine 1jfb, 1jfc, 1ged - FoP450nor 1gej, 1gei - FoP450nor+N-butyl-isocyanide 1ulw - FoP450nor (mutant)


rabbit CYP

2bdm – rCYP2B4 – rabbit 1po5 - rCYP2B4 (mutant) 1suo - rCYP2B4 (mutant)+imidazole 1dt6 - rCYP2C5 (mutant) 1nr6 – rCYP2C5+diclofenac 1n6b - rCYP2C5+sulfaphenazole


Other CYPs

1ued – AoCYP oxyC – Amycolatopsis orientalis 1lfk, 1lg9, 1lgf - AoCYP oxyB 1q5d – ScCYPEPOK+epothilone – Sorangium cellulosum 1q5e - ScCYPEPOK 1io8 – SsCYP119 (mutant) – Sulfolobus solfataricus 1io9, 1io7, 1f4u - SsCYP119 1f4t - SsCYP119+ phenylimidazole 1cpt – CYP108 – Pseudomonas sp. 2uwh - BmCYP102+palmitic acid 3ekb, 3ekd, 3ekf, 2ij3, 2ij4 - BmCYP102 heme domain (mutant) 2ij2, 2hpd - BmCYP102 heme domain 3ben - BmCYP102 + imidazole derivative 2j1m, 2j4s - BmCYP102+DMSO 1bvy, 1bu7– BmCYP102A1 FMN domain 1fag – BmCYP102A1+ palmitic acid 1fah – BmCYP102A1 (mutant) 2bmh - BmCYP102A1 3aba – SaCYP105P1+filipin I – Streptomyces avermitilis 3abb – SaCYP105D6 3e5j, 3e5l - SaCYP105P1 (mutant) 3e5k - SaCYP105P1 (mutant)+4-phenylimidazole 2whw, 2wi9, 2vz7 – SvCYP107L1 (mutant) – Streptomyces venezuelae 2vzm – SvCYP107L1 (mutant)+narbomycin 2c7x - SvCYP107L1+narbomycin 2cd8, 2ca0, 2c6h – SvCYP107L1+YC-17 2bvj - SvCYP107L1 2zqj – BsCYP152A1 – Bacillus subtilis 2zqx - BsCYP152A1+heptanoic acid 1izo – BsCYP BS beta+ palmitoleic acid 1jin, 1jip - SeCYP107A1+ ketoconazole - Saccharopolyspora erythraea 1jio, 1oxa - SeCYP107A1+6DEB 1eup – SeCYP107A1+androstendione 1egy - SeCYP107A1+aminophenanthrene 2jjn, 2jjo - SeCYP113A1 (mutant) 2jjp - SeCYP113A1 (mutant)+ketoconazole 2vrv - SeCYP113A1 (mutant)+clotrimazole 3a1l – SsCYP245A1+dichlorochrompyrrolic acid – Streptomyces sp. 2z3t - SsCYP245A1 2z3u - SsCYP245A1+chromopyrrolic acid 3g5n, 3g93 – rCYP2B4 (mutant)+1-biphenyl-4-methyl-1H-imidazole – rabbit 2q6n – rCYP2B4 (mutant)+chlorophenyl-imidazole 3cv8 – SgCYP105A1 (mutant) – Streptomyces griseolus 3cv9, 2zbz - SgCYP105A1 (mutant)+vitamin D3 2zbx - SgCYP105A1+imidazole 3dam, 3dan, 3dbm– CYP74A2 – Parthenium argentatum 2rch, 3dsi – AtCYP74A+13(S)-HOD – Arabidopsis thaliana 3dsj - AtCYP74A (mutant)+13(S)-HOD 2rcl - AtCYP74A+vernolic acid 3dsk - AtCYP74A (mutant)+ vernolic acid 2rcm, 3cli - AtCYP74A 2rfb – PtCYP – Picrophilus torridus 2rfc – PtCYP+phenylimidazole 2nz5, 2nza, 2dkk – ScCYP158A1 – Streptomyces coelicolor 1gwi - ScCYP154C1 1wiy – TtCYP – Thermus thermophilus 1n97 – TtCYP175A1

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